Accumulating evidence points to an important role of intraneuronal Aβ as a trigger of the
pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's …

In the present report, we extend previous findings in the 5XFAD mouse model and demonstrate
that these mice develop an age-dependent motor phenotype in addition to working …

Alzheimer's disease (AD) is characterized by a substantial degeneration of pyramidal neurons
and the appearance of neuritic plaques and neurofibrillary tangles. Here we present a …

β-Amyloid peptides are key molecules that are involved in the pathology of Alzheimer's
disease (AD). The source and place of the neurotoxic action of Aβ, however, is still a matter of …

The incidence of Alzheimer’s disease (AD), the leading cause of dementia, increases
rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain …

According to the “amyloid hypothesis of Alzheimer's disease,” β-amyloid is the primary driving
force in Alzheimer's disease pathogenesis. Despite the development of many transgenic …

Several novel transgenic mouse models expressing different mutant APPs in combination
with mutant PS1 have been developed. These models have been analyzed to investigate the …

Despite of long-standing evidence that beta-amyloid (Aβ) peptides have detrimental effects
on synaptic function, the relationship between Aβ, synaptic and neuron loss is largely unclear…

Pyroglutamate-modified amyloid-β (Aβ pE3 ) peptides are gaining considerable attention as
potential key participants in the pathology of Alzheimer disease (AD) due to their …

During the last years it has become evident that the β‐amyloid (Aβ) component of senile
plaques may be the key molecule in the pathology of Alzheimer's disease (AD). The source and …