Optic neuropathies such as glaucoma are characterized by the degeneration of retinal
ganglion cells (RGCs) and the irreversible loss of vision. In these diseases, focal axon injury …

Endothelin (EDN, also known as ET) signaling has been suggested to be an important
mediator of retinal ganglion cell (RGC) death in glaucoma. Antagonism of EDN receptors (…

Background Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after
optic nerve damage. BAX activation occurs in two stages including translocation of latent …

Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs),
the output neurons of the retina. Multiple lines of evidence show the endothelin (EDN, …

Glaucoma is an age-related neurodegenerative disease characterized by the progressive
loss of retinal ganglion cells (RGCs). Chronic ocular hypertension, an important risk factor for …

Injury to the axons of retinal ganglion cells (RGCs) is a key pathological event in
glaucomatous neurodegeneration. The transcription factors JUN (the target of the c-Jun N-terminal …

INTRODUCTION In September 2022, The Jackson Laboratory Center for Alzheimer's and
Dementia Research (JAX CADR) hosted a workshop with leading researchers in the …

Glaucoma, a leading cause of irreversible blindness, is characterized by loss of retinal ganglion
cells (RGCs). In glaucoma, RGCs are thought to sustain axonal injury at the glial lamina […

We report on the development of fluorescence Gabor domain optical coherence microscopy
(Fluo GD-OCM), a combination of GD-OCM with laser scanning confocal fluorescence …

Background: Age is the principal risk factor for neurodegeneration in both the retina and brain.
The retina and brain share many biological properties; thus, insights into retinal aging and …