Clinical responses to anticancer therapies are often restricted to a subset of patients. In some
cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here…

Malignant rhabdoid tumours (MRTs) are extremely aggressive cancers of early childhood.
They can occur in various locations, mainly the kidney, brain and soft tissues 1 , 2 . …

EWING'S sarcoma and related subtypes of primitive neuroectodermal tumours share a recurrent
and specific t(ll;22) (q24;q12) chromosome translocation 1–8 , the breakpoints of which …

More and more cancer studies use next-generation sequencing (NGS) data to detect various
types of genomic variation. However, even when researchers have such data at hand, …

Neurofibromatosis type 2 (NF2) is a monogenic dominantly inherited disease predisposing
carriers to develop nervous system tumours. To identify the genetic defect, the region …

Background Precise diagnosis of small-round-cell tumors is often a challenge to the
pathologist and the clinical oncologist. In Ewing's sarcomas and related peripheral primitive …

Neuroblastoma, a tumour derived from the peripheral sympathetic nervous system, is one of
the most frequent solid tumours in childhood 1 , 2 . It usually occurs sporadically but familial …

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

The genes involved in the t(12;22)(q13;q12) translocation found recurrently in malignant
melanoma of soft parts have been characterized and shown to form, in four cases studied, …

The identification of subtype-specific translocations has revolutionized the diagnostics of
sarcoma and has provided new insight into oncogenesis. We used RNA-seq to investigate …