Abstract Changes in the transcriptional state of genes have been correlated with their
repositioning within the nuclear space 1 . Tethering reporter genes to the nuclear envelope alone …

The molecular mechanism underlying the retention of intron-containing mRNAs in the nucleus
is not understood. Here, we show that retention of intron-containing mRNAs in yeast is …

Nuclear export of ribosomes requires a subset of nucleoporins and the Ran system, but
specific transport factors have not been identified. Using a large subunit reporter (Rpl25p-eGFP), …

A nuclear GTPase, Nug1p, was identified in a genetic screen for components linked to 60S
ribosomal subunit export. Nug1p cosedimented with nuclear 60S preribosomes and was …

How pre-ribosomes temporally and spatially mature during intranuclear biogenesis is not
known. Here, we report three nucleolar proteins, Noc1p to Noc3p, that are required for …

Chromosome dynamics are recognized to be intimately linked to genomic transactions, yet
the physical principles governing spatial fluctuations of chromatin are still a matter of debate. …

The nonrandom positioning of genes inside eukaryotic cell nuclei is implicated in central
nuclear functions. However, the spatial organization of the genome remains largely uncharted, …

Formation and nuclear export of 60 S pre-ribosomes requires many factors including the
heterodimeric Noc1-Noc2 and Noc2-Noc3 complexes. Here, we report another Noc complex …

Deletion of elongation factor-like 1 (Efl1p), a cytoplasmic GTPase homologous to the
ribosomal translocases EF-G/EF-2, results in nucle(ol)ar pre-rRNA processing and pre-60S …

10.7554/eLife.45002.001 Ribosome biogenesis is a complex and energy-demanding
process requiring tight coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) …