BACKGROUND: Besides transferrin iron, which represents the normal form of circulating
iron, non-transferrin bound iron (NTBI) has been identified in the plasma of patients with …

Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a reduction
in the concentration of the iron regulatory hormone hepcidin, or a reduction in hepcidin–…

Considering that the development of hepatic lesions related to iron overload diseases might
be a result of abnormally expressed hepatic genes, we searched for new genes up-…

Body iron has a very close relationship with the liver. Physiologically, the liver synthesizes
transferrin, in charge of blood iron transport; ceruloplasmin, acting through its ferroxidase …

Hepcidin, a key regulator of iron metabolism, is synthesized by the liver. Hepcidin binds to
the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, …

Originally identified as a gene up-regulated by iron overload in mouse liver, the HEPC gene
encodes hepcidin, the first mammalian liver-specific antimicrobial peptide and potential key …

Background We investigated patients who had unexplained hepatic iron overload and
normal transferrin saturation. Methods 65 patients with a median liver iron concentration of 85 …

Identification of new players in iron metabolism, such as hepcidin, which regulates
ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron …

Labile plasma iron (LPI) represents the redox active component of non–transferrin-bound
iron (NTBI). Its presence in thalassemic patients has been recently reported. The aim of the …

Aceruloplasminemia is an autosomal recessive disease of iron overload associated with
mutation(s) in the ceruloplasmin gene. We report here a new case of aceruloplasminemia in a …