Despite high expression levels at the plasma membrane or in intracellular vesicles,
tetraspanins remain among the most mysterious transmembrane molecules 20 years after their …

Malaria is a vector‐borne infectious disease caused by unicellular parasites of the genus
Plasmodium. These obligate intracellular parasites have the unique capacity to infect and …

A hallmark of Plasmodium development inside its mammalian victim is the remarkable
restriction to the host species. Adaptation to an intracellular life style in specific target cells is …

Plasmodium sporozoites are transmitted through the bite of infected mosquitoes and first
invade the liver of the mammalian host, as an obligatory step of the life cycle of the malaria …

Plasmodium sporozoites are transmitted through the bite of infected mosquitoes and invade
hepatocytes as a first and obligatory step of the parasite life cycle in man. Hepatocyte …

Background Amongst the Plasmodium species in humans, only P. vivax and P. ovale produce
latent hepatic stages called hypnozoites, which are responsible for malaria episodes long …

Plasmodium sporozoites are deposited in the host skin by Anopheles mosquitoes. The
parasites migrate from the dermis to the liver, where they invade hepatocytes through a moving …

Tetraspanins constitute a family of widely expressed integral membrane proteins that
associate extensively with one another and with other membrane proteins to form specific …

Malaria remains the most prevalent vector-borne infectious disease and has the highest rates
of fatality. Current antimalarial drug strategies cure malaria or prevent infections but lack a …

Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and
transmission of the malaria parasite Plasmodium falciparum during blood stage infection. …