PDZ domains (also known as DHR domains or GLGF repeats) are ~90-residue repeats found
in a number of proteins implicated in ion-channel and receptor clustering, and the linking …

Membrane traffic between the endoplasmic reticulum (ER) and Golgi apparatus and through
the Golgi apparatus is a highly regulated process controlled by members of the rab GTPase …

To initiate infection, many viruses enter their host cells by triggering endocytosis following
receptor engagement. However, the mechanisms by which non-enveloped viruses escape the …

A class of anti-virulence compounds, the salicylidene acylhydrazides, has been widely
reported to block the function of the type three secretion system of several Gram-negative …

Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute
sedimentation coefficients and buoyant molar masses of macromolecules and their …

Mammalian pyruvate dehydrogenase multienzyme complex (PDC) is a key metabolic assembly
comprising a 60-meric pentagonal dodecahedral E2 (dihydrolipoamide acetyltransferase…

Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display
a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family …

Reduced numbers of frictional/scattering centers are essential for tractable hydrodynamic
and small-angle scattering data modeling. We present a method for generating medium-…

Increasing rates of antibiotic resistance among Gram-negative pathogens such as
Pseudomonas aeruginosa means alternative approaches to antibiotic development are urgently …

Escherichia coli possesses a number of specific K + influx and efflux systems that maintain
an appropriate intracellular K + concentration. Although regulatory mechanisms have been …