Knowledge of thalamocortical (TC) processing comes mainly from studying core thalamic
systems that project to middle layers of primary sensory cortices. However, most thalamic relay …

Successful spatial navigation is thought to employ a combination of at least two strategies:
the following of landmark cues and path integration. Path integration requires that the brain …

Since the days of Cajal, the CA1 pyramidal cell has arguably received more attention than
any other neuron in the mammalian brain. Hippocampal CA1 pyramidal cells fire spikes with …

Seizures are classically characterized as the expression of hypersynchronous neural activity,
yet the true degree of synchrony in neuronal spiking (action potentials) during human …

Postrhinal cortex, rodent homolog of the primate parahippocampal cortex, processes spatial
and contextual information. Our hypothesis of postrhinal function is that it serves to encode …

Epilepsy is a devastating disease, currently treated with medications, surgery or electrical
stimulation. None of these approaches is totally effective and our ability to control seizures …

The precise neural mechanisms underlying transitions between consciousness and
anesthetic-induced unconsciousness remain unclear. Here, we studied intracortical neuronal …

The granular retrosplenial cortex (RSG) is critical for both spatial and non-spatial behaviors,
but the underlying neural codes remain poorly understood. Here, we use optogenetic circuit …

Epilepsy—the condition of recurrent, unprovoked seizures—manifests in brain voltage
activity with characteristic spatiotemporal patterns. These patterns include stereotyped semi-…

Objective The treatment of focal epilepsies is largely predicated on the concept that there is
a “focus” from which the seizure emanates. Yet, the physiological context that determines if …