User profiles for Omar S. Mabrouk
omar mabroukBiogen Verified email at biogen.com Cited by 3393 |
Mesolimbic dopamine signals the value of work
Dopamine cell firing can encode errors in reward prediction, providing a learning signal to
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
In vivo neurochemical monitoring using benzoyl chloride derivatization and liquid chromatography–mass spectrometry
In vivo neurochemical monitoring using microdialysis sampling is important in neuroscience
because it allows correlation of neurotransmission with behavior, disease state, and drug …
because it allows correlation of neurotransmission with behavior, disease state, and drug …
Benzoyl chloride derivatization with liquid chromatography–mass spectrometry for targeted metabolomics of neurochemicals in biological samples
Widely targeted metabolomic assays are useful because they provide quantitative data on
large groups of related compounds. We report a high performance liquid chromatography-…
large groups of related compounds. We report a high performance liquid chromatography-…
[HTML][HTML] Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress-and drug-induced dopamine release in the rat medial prefrontal cortex
The mechanism (s) by which serotonin modulates dopamine release in the medial prefrontal
cortex is not known, although studies suggest an involvement of 5-HT2 family receptors. We …
cortex is not known, although studies suggest an involvement of 5-HT2 family receptors. We …
LRRK2 inhibition by BIIB122 in healthy participants and patients with Parkinson's disease
…, JJ Chen, R Maciuca, K Fraser, OS Mabrouk… - Movement …, 2023 - Wiley Online Library
Background Leucine‐rich repeat kinase 2 (LRRK2) inhibition is a promising therapeutic
approach for the treatment of Parkinson's disease (PD). Objective The aim of this study was to …
approach for the treatment of Parkinson's disease (PD). Objective The aim of this study was to …
[PDF][PDF] Enkephalin surges in dorsal neostriatum as a signal to eat
AG DiFeliceantonio, OS Mabrouk, RT Kennedy… - Current Biology, 2012 - cell.com
Compulsive overconsumption of reward characterizes disorders ranging from binge eating
to drug addiction. Here, we provide evidence that enkephalin surges in an anteromedial …
to drug addiction. Here, we provide evidence that enkephalin surges in an anteromedial …
Rapid dopamine transmission within the nucleus accumbens: dramatic difference between morphine and oxycodone delivery
…, KA Porter‐Stransky, OS Mabrouk… - European Journal of …, 2014 - Wiley Online Library
While most drugs of abuse increase dopamine neurotransmission, rapid neurochemical
measurements show that different drugs evoke distinct dopamine release patterns within the …
measurements show that different drugs evoke distinct dopamine release patterns within the …
Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons
10.7554/eLife.08352.001 Striatal dysfunction plays an important role in dystonia, but the
striatal cell types that contribute to abnormal movements are poorly defined. We demonstrate …
striatal cell types that contribute to abnormal movements are poorly defined. We demonstrate …
[HTML][HTML] Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic
cause of Parkinson’s disease. Here, we investigated whether the G2019S LRRK2 mutation …
cause of Parkinson’s disease. Here, we investigated whether the G2019S LRRK2 mutation …
Mass Spectrometry “Sensor” for in Vivo Acetylcholine Monitoring
Developing sensors for in vivo chemical monitoring is a daunting challenge. An alternative
approach is to couple sampling methods with online analytical techniques; however, such …
approach is to couple sampling methods with online analytical techniques; however, such …