User profiles for Omer Karin
Omer KarinLecturer, Imperial College London Verified email at ic.ac.uk Cited by 706 |
A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks
Stress activates a complex network of hormones known as the hypothalamic–pituitary–adrenal
(HPA) axis. The HPA axis is dysregulated in chronic stress and psychiatric disorders, but …
(HPA) axis. The HPA axis is dysregulated in chronic stress and psychiatric disorders, but …
[HTML][HTML] Senescent cell turnover slows with age providing an explanation for the Gompertz law
A causal factor in mammalian aging is the accumulation of senescent cells (SnCs). SnCs
cause chronic inflammation, and removing SnCs decelerates aging in mice. Despite their …
cause chronic inflammation, and removing SnCs decelerates aging in mice. Despite their …
Hormone seasonality in medical records suggests circannual endocrine circuits
…, N Mendelsohn-Cohen, O Karin… - Proceedings of the …, 2021 - National Acad Sciences
Hormones control the major biological functions of stress response, growth, metabolism, and
reproduction. In animals, these hormones show pronounced seasonality, with different set-…
reproduction. In animals, these hormones show pronounced seasonality, with different set-…
[PDF][PDF] Epigenetic inheritance of gene silencing is maintained by a self-tuning mechanism based on resource competition
Biological systems can maintain memories over long timescales, with examples including
memories in the brain and immune system. It is unknown how functional properties of memory …
memories in the brain and immune system. It is unknown how functional properties of memory …
Dynamic proteomics of herpes simplex virus infection
The cellular response to viral infection is usually studied at the level of cell populations.
Currently, it remains an open question whether and to what extent cell-to-cell variability impacts …
Currently, it remains an open question whether and to what extent cell-to-cell variability impacts …
Adaptive cyclic exit strategies from lockdown to suppress COVID-19 and allow economic activity
Many countries have applied lockdown that helped suppress COVID-19, but with devastating
economic consequences. Here we propose exit strategies from lockdown that provide …
economic consequences. Here we propose exit strategies from lockdown that provide …
[HTML][HTML] Damage dynamics and the role of chance in the timing of E. coli cell death
Genetically identical cells in the same stressful condition die at different times. The origin of
this stochasticity is unclear; it may arise from different initial conditions that affect the time of …
this stochasticity is unclear; it may arise from different initial conditions that affect the time of …
Senescent cells and the incidence of age‐related diseases
Age‐related diseases such as cancer, cardiovascular disease, kidney failure, and osteoarthritis
have universal features: Their incidence rises exponentially with age with a slope of 6–8…
have universal features: Their incidence rises exponentially with age with a slope of 6–8…
Dynamical compensation in physiological circuits
Biological systems can maintain constant steady‐state output despite variation in biochemical
parameters, a property known as exact adaptation. Exact adaptation is achieved using …
parameters, a property known as exact adaptation. Exact adaptation is achieved using …
[HTML][HTML] Senescent cell accumulation mechanisms inferred from parabiosis
Senescent cells are growth-arrested cells that cause inflammation and play a causal role in
aging. They accumulate with age, and preventing this accumulation delays age-related …
aging. They accumulate with age, and preventing this accumulation delays age-related …