Therapeutic targeting of non-coding RNAs in cancer
O Slaby, R Laga, O Sedlacek - Biochemical journal, 2017 - portlandpress.com
The majority of the human genome encodes RNAs that do not code for proteins. These non-coding
RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and …
RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and …
Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells
…, S Viswanathan, A Darinskas, O Slaby… - Stem cells and …, 2012 - liebertpub.com
Mesenchymal stem/stromal cells (MSCs) comprise a heterogeneous population of cells with
multilineage differentiation potential, the ability to modulate oxidative stress, and secrete …
multilineage differentiation potential, the ability to modulate oxidative stress, and secrete …
[HTML][HTML] A comprehensive review on MAPK: a promising therapeutic target in cancer
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
[HTML][HTML] Novel classes of non-coding RNAs and cancer
J Sana, P Faltejskova, M Svoboda, O Slaby - Journal of translational …, 2012 - Springer
For the many years, the central dogma of molecular biology has been that RNA functions
mainly as an informational intermediate between a DNA sequence and its encoded protein. But …
mainly as an informational intermediate between a DNA sequence and its encoded protein. But …
Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer
…, L Radova, M Sachlova, Z Kosarova, K Slaba… - …, 2016 - academic.oup.com
Early detection of colorectal cancer is the main prerequisite for successful treatment and
reduction of mortality. Circulating microRNAs were previously identified as promising diagnostic…
reduction of mortality. Circulating microRNAs were previously identified as promising diagnostic…
MicroRNA involvement in glioblastoma pathogenesis
J Novakova, O Slaby, R Vyzula, J Michalek - Biochemical and biophysical …, 2009 - Elsevier
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression
levels of several microRNAs have been observed in glioblastomas. Functions and direct …
levels of several microRNAs have been observed in glioblastomas. Functions and direct …
[HTML][HTML] Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined …
L Kubiczkova, F Kryukov, O Slaby, E Dementyeva… - …, 2014 - ncbi.nlm.nih.gov
Multiple myeloma still remains incurable in the majority of cases prompting a further search
for new and better prognostic markers. Emerging evidence has suggested that circulating …
for new and better prognostic markers. Emerging evidence has suggested that circulating …
Circulating miRNAs as new blood-based biomarkers for solid cancers
M Redova, J Sana, O Slaby - Future oncology, 2013 - Future Medicine
miRNAs are short noncoding RNAs that post-transcriptionally regulate gene expression.
miRNAs’ ability to inhibit translation of oncogenes and tumor suppressor genes implies they …
miRNAs’ ability to inhibit translation of oncogenes and tumor suppressor genes implies they …
[HTML][HTML] MicroRNAs in colorectal cancer: translation of molecular biology into clinical application
O Slaby, M Svoboda, J Michalek, R Vyzula - Molecular cancer, 2009 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides in length that
downregulate gene expression during various crucial cell processes such as apoptosis, …
downregulate gene expression during various crucial cell processes such as apoptosis, …
[HTML][HTML] Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma
…, R Lakomy, M Svoboda, R Vyzula, O Slaby - Journal of translational …, 2012 - Springer
Background There is no standard serum biomarker used for diagnosis or early detection of
recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and …
recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and …