Beyond neutralization, antibodies binding to their Fc receptors elicit several innate immune
functions including antibody-dependent complement deposition (ADCD), antibody-…

Ovarian cancer (OC) is a lethal gynecologic malignancy, with modest responses to CPI.
Engagement of additional immune arms, such as NK cells, may be of value. We focused on …

BACKGROUND: Ovarian hormones may contribute to the vulnerability to depression, as well
as to the response to antidepressants (ADs). Previously, we reported that acute systemic …

Sialic acid-binding Immunoglobulin-like lectin-9 (Siglec-9) is a glyco-immune negative
checkpoint expressed on several immune cells. Siglec-9 exerts its inhibitory effects by binding to …

Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, has had a dramatic
global impact on public health and social and economic infrastructures. Here, we assess …

Objective: Worldwide, most new HIV infections occur through mucosal exposure. Immunoglobulin
M (IgM) is the first antibody class generated in response to infectious agents; IgM is …

Siglec-9 is an MHC-independent inhibitory receptor expressed on a subset of natural killer (NK)
cells. Siglec-9 restrains NK cytotoxicity by binding to sialoglycans (sialic acid-containing …

… Kruskal-Wallis tests with Dunn’s multiple comparisons correction were used for statistical …
’s multiple-comparisons correction were used for statistical analyses. (J to M) Spearman’s rank-…

Acute estradiol treatment was reported to slow the clearance of serotonin via activation of
estrogen receptors (ER) β and/or GPR30 and to block the ability of a selective serotonin …

People living with HIV (PLWH) experience increased vulnerability to premature aging and
inflammation-associated comorbidities, even when HIV replication is suppressed by …