The gut microbiome has been shown to influence the response of tumors to anti–PD-1 (programmed
cell death–1) immunotherapy in preclinical mouse models and observational …

The increasing resistance of bacteria to conventional antibiotics resulted in a strong effort to
develop antimicrobial compounds with new mechanisms of action. Antimicrobial peptides …

The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic
α-helical peptide isolated from human. LL-37 is considered to play an important role in the …

Studies on lipid−peptide interactions of cytolytic polypeptides tend to emphasize the
importance of the amphipathic α-helical structure for their cytolytic activity. In this study, …

Living organisms of all types produce a large repertoire of gene-encoded, net positively
charged, antimicrobial peptides as part of their innate immunity to microbial invasion. Despite …

Pardaxin, a 33‐amino‐acid pore‐forming polypetide toxin isolated from the Red Sea Moses
sole Pardachirus marmoratus, has a helix‐hinge‐helix structure. This is a common structural …

The search for antibiotics with a new mode of action led to numerous studies on antibacterial
peptides. Most of the studies were carried out with l-amino acid peptides possessing …

Exposure to antibiotics in the first days of life is thought to affect various physiological aspects
of neonatal development. Here, we investigate the long-term impact of antibiotic treatment …

Objective Radiation proctitis (RP) is a complication of pelvic radiotherapy which affects both
the host and microbiota. Herein we assessed the radiation effect on microbiota and its …

There are persistent differences in self-reported subjective well-being across US metropolitan
areas, and residents of declining cities appear less happy than others. Yet some people …