10.7554/eLife.36354.001 Matrix stiffening with downstream activation of mechanosensitive
pathways is strongly implicated in progressive fibrosis; however, pathologic changes in …

Two‐photon polymerization (2PP) is a lithography‐based 3D printing method allowing the
fabrication of 3D structures with sub‐micrometer resolution. This work focuses on the …

Cartilage grafts generated using conventional static tissue engineering strategies are
characterised by low cell viability, suboptimal hyaline cartilage formation and, critically, inferior …

Photodegradable hydrogels have emerged as useful platforms for research on cell function,
tissue engineering, and cell delivery as their physical and chemical properties can be …

Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive
pathways is strongly implicated in fibrosis. We previously reported that altered collagen …

The nanomechanical assessment of collagen fibrils via atomic force microscopy (AFM) is of
increasing interest within the biomedical research community. In contrast to conventional …

An improved understanding of bone mechanics is vital in the development of evaluation
strategies for patients at risk of bone fracture. The current evaluation approach based on bone …

Tissue hydration is well known to influence tissue mechanics and can be tuned via osmotic
pressure. Collagen fibrils are nature’s nanoscale building blocks to achieve biomechanical …

Collagen fibrils are the fundamental structural elements in vertebrate animals and compose
a structural framework that provides mechanical support to load-bearing tissues. …

Accumulation of advanced glycation end-products (AGEs) in biological tissues occurs as a
consequence of normal ageing and pathology. Most biological tissues are composed of …