ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation
…, M Lysenko, T Konfino, J Hegesh, O Brenner… - Nature cell …, 2015 - nature.com
The murine neonatal heart can regenerate after injury through cardiomyocyte (CM) proliferation,
although this capacity markedly diminishes after the first week of life. Neuregulin-1 (…
although this capacity markedly diminishes after the first week of life. Neuregulin-1 (…
[PDF][PDF] Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and sensed by
most hematopoietic cells. Genome-wide association studies and experimental animal models …
most hematopoietic cells. Genome-wide association studies and experimental animal models …
[HTML][HTML] The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons
…, C Xiao, M Fliegauf, E Kremer, F Otto, O Brenner… - The EMBO …, 2002 - embopress.org
The RUNX transcription factors are important regulators of linage‐specific gene expression
in major developmental pathways. Recently, we demonstrated that Runx3 is highly …
in major developmental pathways. Recently, we demonstrated that Runx3 is highly …
[PDF][PDF] Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs
In vitro cultured stem cells with distinct developmental capacities can contribute to embryonic
or extraembryonic tissues after microinjection into pre-implantation mammalian embryos. …
or extraembryonic tissues after microinjection into pre-implantation mammalian embryos. …
Caspase-8 serves both apoptotic and nonapoptotic roles
…, A Jurewicz, A Waisman, O Brenner… - The Journal of …, 2004 - journals.aai.org
Knockout of caspase-8, a cysteine protease that participates in the signaling for cell death by
receptors of the TNF/nerve growth factor family, is lethal to mice in utero. To explore tissue-…
receptors of the TNF/nerve growth factor family, is lethal to mice in utero. To explore tissue-…
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis
…, D Goldenberg, O Brenner… - Proceedings of the …, 2003 - National Acad Sciences
The RUNX transcription factors are important regulators of lineage-specific gene expression.
RUNX are bifunctional, acting both as activators and repressors of tissue-specific target …
RUNX are bifunctional, acting both as activators and repressors of tissue-specific target …
Runx3 regulates mouse TGF‐β‐mediated dendritic cell function and its absence results in airway inflammation
…, E Woolf, J Lotem, M Yarmus, O Brenner… - The EMBO …, 2004 - embopress.org
Runx3 transcription factor regulates cell lineage decisions in thymopoiesis and neurogenesis.
Here we report that Runx3 knockout (KO) mice develop spontaneous eosinophilic lung …
Here we report that Runx3 knockout (KO) mice develop spontaneous eosinophilic lung …
[HTML][HTML] Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome
…, D Makia, R Krauthgamer, O Brenner… - Immunity, 2008 - cell.com
Dendritic cells are critically involved in the promotion and regulation of T cell responses. Here,
we report a mouse strain that lacks conventional CD11c hi dendritic cells (cDCs) because …
we report a mouse strain that lacks conventional CD11c hi dendritic cells (cDCs) because …
Photodynamic therapy with Pd‐bacteriopheophorbide (TOOKAD): Successful in vivo treatment of human prostatic small cell carcinoma xenografts
…, JH Pinthus, A Brandis, O Brenner… - … journal of cancer, 2003 - Wiley Online Library
Small cell carcinoma of the prostate (SCCP), although relatively rare, is the most aggressive
variant of prostate cancer, currently with no successful treatment. It was therefore tempting to …
variant of prostate cancer, currently with no successful treatment. It was therefore tempting to …
[HTML][HTML] A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy
Y Pewzner-Jung, O Brenner, S Braun, EL Laviad… - Journal of Biological …, 2010 - ASBMB
We have generated a mouse that cannot synthesize very long acyl chain (C22–C24) ceramides
(Pewzner-Jung, Y., Park, H., Laviad, EL, Silva, LC, Lahiri, S., Stiban, J., Erez-Roman, R., …
(Pewzner-Jung, Y., Park, H., Laviad, EL, Silva, LC, Lahiri, S., Stiban, J., Erez-Roman, R., …