The dendritic protrusions known as spines represent the primary postsynaptic location for
excitatory synapses. Dendritic spines are critical for many synaptic functions, and their …

Several lines of evidence place alpha-synuclein (aSyn) at the center of Parkinson's disease
(PD) etiology, but it is still unclear why overexpression or mutated forms of this protein affect …

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved pathway
in which proteins and organelles are delivered to the lysosome for degradation. In neurons…

The most common genetic risk factors for Parkinson’s disease (PD) are a set of heterozygous
mutant (MT) alleles of the GBA1 gene that encodes β-glucocerebrosidase (GCase), an …

The rise of bacterial resistance to traditional antibiotics has motivated recent efforts to identify
new drug candidates that target virulence factors or their regulatory pathways. One such …

Neural circuits are formed and refined during childhood, including via critical changes in
neuronal excitability. Here, we investigated the ontogeny of striatal intrinsic excitability. We …

Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by a loss
of dopaminergic neurons in the substantia nigra (SN). Although mitochondrial dysfunction …

Midbrain dopaminergic (mDA) neurons exhibit extensive dendritic and axonal arborizations,
but local protein synthesis is not characterized in these neurons. Here, we investigate …

Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired
as high-value partners for combination therapies. Here, we report the identification and …

The basal ganglia are a group of subcortical nuclei that contribute to action selection and
reinforcement learning. The principal neurons of the striatum, spiny projection neurons of the …