[HTML][HTML] Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating protein (TRAP)
…, HR Matthews, RT Nhan, B Singh, O Uziel - Journal of Biological …, 2001 - ASBMB
Staphylococcus aureus can cause disease through the production of toxins. Toxin production
is autoinduced by the protein RNAIII-activating protein (RAP) and by the autoinducing …
is autoinduced by the protein RNAIII-activating protein (RAP) and by the autoinducing …
Transcriptional Regulation of the Staphylococcus aureus Thioredoxin and Thioredoxin Reductase Genes in Response to Oxygen and Disulfide Stress
O Uziel, I Borovok, R Schreiber, G Cohen… - Journal of …, 2004 - Am Soc Microbiol
In this report we describe the cloning, organization, and promoter analysis of the Staphylococcus
aureus thioredoxin (trxA) and thioredoxin reductase (trxB) genes and their transcription …
aureus thioredoxin (trxA) and thioredoxin reductase (trxB) genes and their transcription …
Telomere dynamics in arteries and mononuclear cells of diabetic patients: effect of diabetes and of glycemic control
O Uziel, JA Singer, V Danicek, G Sahar, E Berkov… - Experimental …, 2007 - Elsevier
Telomeres serve as a mitotic clock and biological marker of senescence. Diabetes mellitus (DM)
is associated with damage to target organs and premature aging. We assessed the …
is associated with damage to target organs and premature aging. We assessed the …
[HTML][HTML] Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells
A Gutkin, O Uziel, E Beery, J Nordenberg, M Pinchasi… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Exosomes are small (30-100nm) vesicles secreted from all cell types serving as inter-cell
communicators and affecting biological processes in “recipient” cells upon their uptake. The …
communicators and affecting biological processes in “recipient” cells upon their uptake. The …
Lymphoma and leukemia cells possess fractal dimensions that correlate with their biological features
A Mashiah, O Wolach, J Sandbank, O Uziel… - Acta …, 2008 - karger.com
Background: Living cells can be viewed as complex adaptive systems that exhibit non-linear
dynamics and fractal features. We investigated the fractal qualities of normal and malignant …
dynamics and fractal features. We investigated the fractal qualities of normal and malignant …
[HTML][HTML] Characterisation of blood-derived exosomal hTERT mRNA secretion in cancer patients: a potential pan-cancer marker
…, J Nordenberg, O Wolach, E Rabizadeh, O Uziel… - British journal of …, 2017 - nature.com
Background: Telomerase (human telomerase reverse transcriptase (hTERT)) is considered
a hallmark of cancer. The aim of our study was to evaluate the feasibility of the detection of …
a hallmark of cancer. The aim of our study was to evaluate the feasibility of the detection of …
Is serum‐derived exosomal hTERT transcript a marker of oncogenic activity in primary brain tumors? An exploratory study
O Uziel, AA Kanner, E Beery, S Lev, M Lahav… - Cancer …, 2024 - Wiley Online Library
Background In order to proliferate indefinitely, all tumors require a telomere maintenance
mechanism. The expression of human telomerase reverse transcriptase (hTERT) enables …
mechanism. The expression of human telomerase reverse transcriptase (hTERT) enables …
In vitro novel combinations of psychotropics and anti-cancer modalities in U87 human glioblastoma cells
…, E Beery, M Israeli, O Uziel… - International …, 2010 - spandidos-publications.com
Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor. Despite some
recent improvement in the treatment of this malignancy, life expectancy of GBM patients …
recent improvement in the treatment of this malignancy, life expectancy of GBM patients …
[HTML][HTML] The effect of ethanol on telomere dynamics and regulation in human cells
…, E Beery, Y Edel, M Lahav, U Rozovski, O Uziel - Cells, 2018 - mdpi.com
Telomeres (TLs) protect chromosome ends from chromosomal fusion and degradation, thus
conferring genomic stability, and play crucial roles in cellular aging and disease. Recent …
conferring genomic stability, and play crucial roles in cellular aging and disease. Recent …
[HTML][HTML] Exosomal telomerase transcripts reprogram the microRNA transcriptome profile of fibroblasts and partially contribute to CAF formation
It is now well accepted that cancer cells change their microenvironment from normal to tumor-supportive
state to provide sustained tumor growth, metastasis and drug resistance. These …
state to provide sustained tumor growth, metastasis and drug resistance. These …