[HTML][HTML] Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating protein (TRAP)

…, HR Matthews, RT Nhan, B Singh, O Uziel - Journal of Biological …, 2001 - ASBMB
Staphylococcus aureus can cause disease through the production of toxins. Toxin production
is autoinduced by the protein RNAIII-activating protein (RAP) and by the autoinducing …

Transcriptional Regulation of the Staphylococcus aureus Thioredoxin and Thioredoxin Reductase Genes in Response to Oxygen and Disulfide Stress

O Uziel, I Borovok, R Schreiber, G Cohen… - Journal of …, 2004 - Am Soc Microbiol
In this report we describe the cloning, organization, and promoter analysis of the Staphylococcus
aureus thioredoxin (trxA) and thioredoxin reductase (trxB) genes and their transcription …

Telomere dynamics in arteries and mononuclear cells of diabetic patients: effect of diabetes and of glycemic control

O Uziel, JA Singer, V Danicek, G Sahar, E Berkov… - Experimental …, 2007 - Elsevier
Telomeres serve as a mitotic clock and biological marker of senescence. Diabetes mellitus (DM)
is associated with damage to target organs and premature aging. We assessed the …

[HTML][HTML] Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells

A Gutkin, O Uziel, E Beery, J Nordenberg, M Pinchasi… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Exosomes are small (30-100nm) vesicles secreted from all cell types serving as inter-cell
communicators and affecting biological processes in “recipient” cells upon their uptake. The …

Lymphoma and leukemia cells possess fractal dimensions that correlate with their biological features

A Mashiah, O Wolach, J Sandbank, O Uziel… - Acta …, 2008 - karger.com
Background: Living cells can be viewed as complex adaptive systems that exhibit non-linear
dynamics and fractal features. We investigated the fractal qualities of normal and malignant …

[HTML][HTML] Characterisation of blood-derived exosomal hTERT mRNA secretion in cancer patients: a potential pan-cancer marker

…, J Nordenberg, O Wolach, E Rabizadeh, O Uziel… - British journal of …, 2017 - nature.com
Background: Telomerase (human telomerase reverse transcriptase (hTERT)) is considered
a hallmark of cancer. The aim of our study was to evaluate the feasibility of the detection of …

Is serum‐derived exosomal hTERT transcript a marker of oncogenic activity in primary brain tumors? An exploratory study

O Uziel, AA Kanner, E Beery, S Lev, M Lahav… - Cancer …, 2024 - Wiley Online Library
Background In order to proliferate indefinitely, all tumors require a telomere maintenance
mechanism. The expression of human telomerase reverse transcriptase (hTERT) enables …

In vitro novel combinations of psychotropics and anti-cancer modalities in U87 human glioblastoma cells

…, E Beery, M Israeli, O Uziel… - International …, 2010 - spandidos-publications.com
Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor. Despite some
recent improvement in the treatment of this malignancy, life expectancy of GBM patients …

[HTML][HTML] The effect of ethanol on telomere dynamics and regulation in human cells

…, E Beery, Y Edel, M Lahav, U Rozovski, O Uziel - Cells, 2018 - mdpi.com
Telomeres (TLs) protect chromosome ends from chromosomal fusion and degradation, thus
conferring genomic stability, and play crucial roles in cellular aging and disease. Recent …

[HTML][HTML] Exosomal telomerase transcripts reprogram the microRNA transcriptome profile of fibroblasts and partially contribute to CAF formation

…, A Gervits, R Sharan, M Lahav, P Raanani, O Uziel - Scientific Reports, 2022 - nature.com
It is now well accepted that cancer cells change their microenvironment from normal to tumor-supportive
state to provide sustained tumor growth, metastasis and drug resistance. These …