User profiles for Orsolya Symmons

Orsolya Symmons

COCIR
Verified email at age.mpg.de
Cited by 2236

Phenotypic impact of genomic structural variation: insights from and for human disease

J Weischenfeldt, O Symmons, F Spitz… - Nature Reviews …, 2013 - nature.com
Genomic structural variants have long been implicated in phenotypic diversity and human
disease, but dissecting the mechanisms by which they exert their functional impact has proven …

Functional and topological characteristics of mammalian regulatory domains

O Symmons, VV Uslu, T Tsujimura, S Ruf… - Genome …, 2014 - genome.cshlp.org
Long-range regulatory interactions play an important role in shaping gene-expression
programs. However, the genomic features that organize these activities are still poorly …

[PDF][PDF] The Shh topological domain facilitates the action of remote enhancers by reducing the effects of genomic distances

O Symmons, L Pan, S Remeseiro, T Aktas, F Klein… - Developmental cell, 2016 - cell.com
Gene expression often requires interaction between promoters and distant enhancers,
which occur within the context of highly organized topologically associating domains (TADs). …

[PDF][PDF] What's luck got to do with it: single cells, multiple fates, and biological nondeterminism

O Symmons, A Raj - Molecular cell, 2016 - cell.com
The field of single-cell biology has morphed from a philosophical digression at its inception,
to a playground for quantitative biologists, to a major area of biomedical research. The last …

Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor

S Ruf, O Symmons, VV Uslu, D Dolle, C Hot… - Nature …, 2011 - nature.com
We present here a Sleeping Beauty–based transposition system that offers a simple and
efficient way to investigate the regulatory architecture of mammalian chromosomes in vivo. With …

ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification

…, S Bayatpour, CL Jiang, I Dardani, O Symmons… - Nature …, 2019 - nature.com
Methods for detecting single nucleic acids in cell and tissues, such as fluorescence in situ
hybridization (FISH), are limited by relatively low signal intensity and nonspecific probe binding…

A survey-based analysis of the academic job market

…, AJ Kozik, AS Holehouse, V Pejaver, O Symmons… - Elife, 2020 - elifesciences.org
Many postdoctoral researchers apply for faculty positions knowing relatively little about the
hiring process or what is needed to secure a job offer. To address this lack of knowledge …

Cis-regulatory architecture of a brain signaling center predates the origin of chordates

…, YT Zhao, Y Jeong, AM Pani, AN King, O Symmons… - Nature …, 2016 - nature.com
Genomic approaches have predicted hundreds of thousands of tissue-specific cis-regulatory
sequences, but the determinants critical to their function and evolutionary history are mostly …

Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

…, M Xie, A Kicheva, K Annusver, M Kasper, O Symmons… - Elife, 2018 - elifesciences.org
10.7554/eLife.34465.001 Facial shape is the basis for facial recognition and categorization.
Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that …

[PDF][PDF] Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro

…, HI Edelstein, R Truitt, Y Goyal, LE Beck, O Symmons… - Cell systems, 2021 - cell.com
Identifying the particular transcription factors that maintain cell type in vitro is important for
manipulating cell type. Identifying such transcription factors by their cell-type-specific …