User profiles for Orsolya Symmons
Orsolya SymmonsCOCIR Verified email at age.mpg.de Cited by 2236 |
Phenotypic impact of genomic structural variation: insights from and for human disease
J Weischenfeldt, O Symmons, F Spitz… - Nature Reviews …, 2013 - nature.com
Genomic structural variants have long been implicated in phenotypic diversity and human
disease, but dissecting the mechanisms by which they exert their functional impact has proven …
disease, but dissecting the mechanisms by which they exert their functional impact has proven …
Functional and topological characteristics of mammalian regulatory domains
Long-range regulatory interactions play an important role in shaping gene-expression
programs. However, the genomic features that organize these activities are still poorly …
programs. However, the genomic features that organize these activities are still poorly …
[PDF][PDF] The Shh topological domain facilitates the action of remote enhancers by reducing the effects of genomic distances
Gene expression often requires interaction between promoters and distant enhancers,
which occur within the context of highly organized topologically associating domains (TADs). …
which occur within the context of highly organized topologically associating domains (TADs). …
[PDF][PDF] What's luck got to do with it: single cells, multiple fates, and biological nondeterminism
The field of single-cell biology has morphed from a philosophical digression at its inception,
to a playground for quantitative biologists, to a major area of biomedical research. The last …
to a playground for quantitative biologists, to a major area of biomedical research. The last …
Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor
We present here a Sleeping Beauty–based transposition system that offers a simple and
efficient way to investigate the regulatory architecture of mammalian chromosomes in vivo. With …
efficient way to investigate the regulatory architecture of mammalian chromosomes in vivo. With …
ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification
Methods for detecting single nucleic acids in cell and tissues, such as fluorescence in situ
hybridization (FISH), are limited by relatively low signal intensity and nonspecific probe binding…
hybridization (FISH), are limited by relatively low signal intensity and nonspecific probe binding…
A survey-based analysis of the academic job market
Many postdoctoral researchers apply for faculty positions knowing relatively little about the
hiring process or what is needed to secure a job offer. To address this lack of knowledge …
hiring process or what is needed to secure a job offer. To address this lack of knowledge …
Cis-regulatory architecture of a brain signaling center predates the origin of chordates
Genomic approaches have predicted hundreds of thousands of tissue-specific cis-regulatory
sequences, but the determinants critical to their function and evolutionary history are mostly …
sequences, but the determinants critical to their function and evolutionary history are mostly …
Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage
10.7554/eLife.34465.001 Facial shape is the basis for facial recognition and categorization.
Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that …
Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that …
[PDF][PDF] Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro
Identifying the particular transcription factors that maintain cell type in vitro is important for
manipulating cell type. Identifying such transcription factors by their cell-type-specific …
manipulating cell type. Identifying such transcription factors by their cell-type-specific …