GENOMIC imprinting has been implicated in the onset of several embryonal tumours but the
mechanism is not well understood 1–3 . Maternal chromosome 11p15 loss of …

Background Survival outcomes are poor for patients with metastatic urothelial carcinoma
who receive standard, first-line, platinum-based chemotherapy. We assessed the overall …

To construct an East Asia mitochondrial DNA (mtDNA) phylogeny, we sequenced the
complete mitochondrial genomes of 672 Japanese individuals (http://www. giib. or. jp/mtsnp/…

ABSTRACT. Renal excretion of organic anions and cations is mediated by the organic ion
transporter family (SLC22A). In this study, the mRNA levels of the organic ion transporters …

The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …

Malfunction of the circadian clock has been linked to the pathogenesis of a variety of
diseases. We show that mice lacking the core clock components Cryptochrome-1 (Cry1) and …

The substrate specificities of human (h) multidrug and toxin extrusion (MATE) 1 and hMATE2-K
were examined to find functional differences between these two transporters by the …

A cDNA coding a new H+/organic cation antiporter, human kidney-specific multidrug and toxin
extrusion 2 (hMATE2-K), has been isolated from the human kidney. The hMATE2-K cDNA …

Mitogen-activated protein kinases (MAPKs) play a pivotal role in the mitogenic signal
transduction pathway and are essential components of the MAPK cascade, which includes MEK (…

Prostate cancer is one of the most common malignancies in males throughout the world 1 ,
and its incidence is increasing in Asian countries. We carried out a genome-wide association …