Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
…, A Koné, DA Diallo, A Raza, O Kai… - Proceedings of the …, 2007 - National Acad Sciences
Malaria has been a major selective force on the human population, and several erythrocyte
polymorphisms have evolved that confer resistance to severe malaria. Plasmodium …
polymorphisms have evolved that confer resistance to severe malaria. Plasmodium …
Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria
A Pain, DJP Ferguson, O Kai… - Proceedings of the …, 2001 - National Acad Sciences
Sequestration of malaria-infected erythrocytes in the peripheral circulation has been
associated with the virulence of Plasmodium falciparum. Defining the adhesive phenotypes of …
associated with the virulence of Plasmodium falciparum. Defining the adhesive phenotypes of …
[PDF][PDF] Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq)
to examine the diversity of both antigen-specific and total B cells in healthy …
to examine the diversity of both antigen-specific and total B cells in healthy …
Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo
C Casals-Pascual, O Kai, JOP Cheung, S Williams… - Blood, 2006 - ashpublications.org
Malarial anemia is a global public health problem and is characterized by a low reticulocyte
response in the presence of life-threatening hemolysis. Although cytokines, in particular …
response in the presence of life-threatening hemolysis. Although cytokines, in particular …
Fresh Isolates from Children with Severe Plasmodium falciparum Malaria Bind to Multiple Receptors
A Heddini, F Pettersson, O Kai, J Shafi… - Infection and …, 2001 - Am Soc Microbiol
The sequestration of Plasmodium falciparum-infected erythrocytes (pRBC) away from the
peripheral circulation is a property of all field isolates. Here we have examined the pRBC of …
peripheral circulation is a property of all field isolates. Here we have examined the pRBC of …
[HTML][HTML] A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya
Objective The objective was to measure the efficacy of the vaccination regimen FFM ME-TRAP
in preventing episodes of clinical malaria among children in a malaria endemic area. …
in preventing episodes of clinical malaria among children in a malaria endemic area. …
Nonimmune IgM, but not IgG binds to the surface of Plasmodium falciparum-infected erythrocytes and correlates with rosetting and severe malaria.
Recent work suggests that IgG and IgM from nonimmune human serum (natural antibodies)
bind to the surface of Plasmodium falciparum-infected erythrocytes and contribute to rosette …
bind to the surface of Plasmodium falciparum-infected erythrocytes and contribute to rosette …
[HTML][HTML] Circumsporozoite-Specific T Cell Responses in Children Vaccinated with RTS,S/AS01E and Protection against P falciparum Clinical Malaria
…, J Vekemans, D Kimani, M Janssens, O Kai… - PloS one, 2011 - journals.plos.org
Background RTS,S/AS01 E is the lead candidate pre-erythrocytic malaria vaccine. In Phase
IIb field trials the safety profile was acceptable and the efficacy was 53% (95%CI 31%–72%) …
IIb field trials the safety profile was acceptable and the efficacy was 53% (95%CI 31%–72%) …
A non-sense mutation in Cd36 gene is associated with protection from severe malaria
We sought genetic evidence for the importance of host-parasite interactions involving CD36
in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the …
in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the …
The induction and persistence of T cell IFN-γ responses after vaccination or natural exposure is suppressed by Plasmodium falciparum
Epidemiological observations suggest that T cell immunity may be suppressed in malaria-endemic
areas. In vitro studies, animal models, and limited data in humans link …
areas. In vitro studies, animal models, and limited data in humans link …