The incomplete identification of structural variants (SVs) from whole-genome sequencing
data limits studies of human genetic diversity and disease association. Here, we apply a suite …

New technologies and analysis methods are enabling genomic structural variants (SVs) to
be detected with ever-increasing accuracy, resolution and comprehensiveness. To help …

Conventional immunization strategies will likely be insufficient for the development of a broadly
neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of the …

The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently, (auto)antigen recognition. Emerging evidence …

Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …

Immunogenomics studies have been largely limited to individuals of European ancestry,
restricting the ability to identify variation in human adaptive immune responses across …

An incomplete ascertainment of genetic variation within the highly polymorphic immunoglobulin
heavy chain locus (IGH) has hindered our ability to define genetic factors that influence …

New technologies and analysis methods are enabling genomic structural variants (SVs) to
be detected with ever-increasing accuracy, resolution, and comprehensiveness. Translating …

Immunoglobulins (IGs), crucial components of the adaptive immune system, are encoded by
three genomic loci. However, the complexity of the IG loci severely limits the effective use of …

There is growing recognition that epivariations, most often recognized as promoter hypermethylation
events that lead to gene silencing, are associated with a number of human diseases…