User profiles for Oscar P. B. Wiklander

Oscar PB Wiklander

Senior researcher, Karolinska institutet
Verified email at ki.se
Cited by 4677

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

OPB Wiklander, JZ Nordin, A O'Loughlin… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication
in a diverse range of biological processes. For future therapeutic applications and for …

Advances in therapeutic applications of extracellular vesicles

OPB Wiklander, MÁ Brennan, J Lötvall… - Science translational …, 2019 - science.org
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles secreted
by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of …

[HTML][HTML] Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

…, HJ Johansson, W Heusermann, OPB Wiklander… - … , Biology and Medicine, 2015 - Elsevier
Extracellular vesicles (EVs) are natural nanoparticles that mediate intercellular transfer of
RNA and proteins and are of great medical interest; serving as novel biomarkers and potential …

Identification of storage conditions stabilizing extracellular vesicles preparations

…, DW Hagey, R Jawad Wiklander… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) play a key role in many physiological and pathophysiological
processes and hold great potential for therapeutic and diagnostic use. Despite significant …

[HTML][HTML] Systematic methodological evaluation of a multiplex bead-based flow cytometry assay for detection of extracellular vesicle surface signatures

OPB Wiklander, RB Bostancioglu, JA Welsh… - Frontiers in …, 2018 - frontiersin.org
Extracellular vesicles (EVs) can be harvested from cell culture supernatants and from all
body fluids. EVs can be conceptually classified based on their size and biogenesis as …

In vivo effects of mesenchymal stromal cells in two patients with severe acute respiratory distress syndrome

…, S El Andaloussi, OPB Wiklander… - Stem cells …, 2015 - academic.oup.com
This article describes the cases of two patients with severe refractory adult respiratory
syndrome (ARDS) who failed to improve after both standard life support measures, including …

[HTML][HTML] Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice

H Aswad, A Forterre, OPB Wiklander, G Vial… - Diabetologia, 2014 - Springer
Aims/hypothesis Exosomes released from cells can transfer both functional proteins and
RNAs between cells. In this study we tested the hypothesis that muscle cells might transmit …

Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles

…, P Vader, JZ Nordin, OPB Wiklander… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs) play a significant role in cell–cell communication in numerous
physiological processes and pathological conditions, and offer promise as novel biomarkers …

[HTML][HTML] Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice

A Jalabert, G Vial, C Guay, OPB Wiklander, JZ Nordin… - Diabetologia, 2016 - Springer
Aims/hypothesis The crosstalk between skeletal muscle (SkM) and beta cells plays a role in
diabetes aetiology. In this study, we have investigated whether SkM-released exosome-like …

[HTML][HTML] Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

…, HJ Johansson, JZ Nordin, OPB Wiklander… - Scientific reports, 2018 - nature.com
Extracellular vesicles (EVs) mediate cell-to-cell communication by delivering or displaying
macromolecules to their recipient cells. While certain broad-spectrum EV effects reflect their …