User profiles for Osman Shabir
 | Osman ShabirPostdoctoral Research Fellow (BHF), University of Sheffield Verified email at sheffield.ac.uk Cited by 362 |
[HTML][HTML] Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer's disease
Early impairments to neurovascular coupling have been proposed to be a key pathogenic
factor in the onset and progression of Alzheimer’s disease (AD). Studies have shown impaired …
factor in the onset and progression of Alzheimer’s disease (AD). Studies have shown impaired …
[HTML][HTML] Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis
Efficient blood supply to the brain is of paramount importance to its normal functioning and
improper blood flow can result in potentially devastating neurological consequences. …
improper blood flow can result in potentially devastating neurological consequences. …
[HTML][HTML] Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis
…, H An, P Dimasi, S Alexeeva, O Shabir… - Molecular …, 2018 - Springer
Background Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA)
NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral …
NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral …
Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer's disease
Neurovascular coupling is a critical brain mechanism whereby changes to blood flow
accompany localised neural activity. The breakdown of neurovascular coupling is linked to the …
accompany localised neural activity. The breakdown of neurovascular coupling is linked to the …
Neurovascular coupling preserved in a chronic mouse model of Alzheimer's disease: Methodology is critical
Impaired neurovascular coupling has been suggested as an early pathogenic factor in
Alzheimer’s disease (AD), which could serve as an early biomarker of cerebral pathology. We …
Alzheimer’s disease (AD), which could serve as an early biomarker of cerebral pathology. We …
[HTML][HTML] Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo
Neurovascular coupling (NVC) is a mechanism that, amongst other known and latent critical
functions, ensures activated brain regions are adequately supplied with oxygen and glucose…
functions, ensures activated brain regions are adequately supplied with oxygen and glucose…
[HTML][HTML] The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice
Investigating neurovascular coupling in awake rodents is becoming ever more popular due,
in part, to our increasing knowledge of the profound impacts that anaesthesia can have …
in part, to our increasing knowledge of the profound impacts that anaesthesia can have …
Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia
The use of animal models is fundamental to furthering our understanding of human disease
mechanisms, as well as identifying potential therapeutic targets. Diseases of ageing often …
mechanisms, as well as identifying potential therapeutic targets. Diseases of ageing often …
Assessment of neurovascular coupling & cortical spreading depression in mixed models of atherosclerosis & alzheimer's disease
Neurovascular coupling is a critical brain mechanism whereby changes to blood flow
accompany localised neural activity. The breakdown of neurovascular coupling is linked to the …
accompany localised neural activity. The breakdown of neurovascular coupling is linked to the …
How does alzheimer's disease, atherosclerosis and comorbid alzheimer's disease and atherosclerosis impact neurovascular function?
Background The brain is an energy hungry organ, consuming approximately 20% of the
body’s energy supply (Clark & Sokoloff 1999). Due to its high energy demands the brain has …
body’s energy supply (Clark & Sokoloff 1999). Due to its high energy demands the brain has …