Just as in clay moulding or glass blowing, physically sculpting biological structures requires
the constituent material to locally flow like a fluid while maintaining overall mechanical …

Cell-generated mechanical forces play a critical role during tissue morphogenesis and organ
formation in the embryo. Little is known about how these forces shape embryonic organs, …

The mechanical properties of the cellular microenvironment and their spatiotemporal
variations are thought to play a central role in sculpting embryonic tissues, maintaining organ …

The physical state of embryonic tissues emerges from non-equilibrium, collective interactions
among constituent cells. Cellular jamming, rigidity transitions and characteristics of glassy …

The sculpting of embryonic tissues and organs into their functional morphologies involves
the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in vitro …

Tissue morphogenesis, homoeostasis and repair require cells to constantly monitor their
three-dimensional microenvironment and adapt their behaviours in response to local …

During embryogenesis, tissues and organs are progressively shaped into their functional
morphologies. While the information about tissue and organ shape is encoded genetically, the …

In eukaryotic cells, nanotubes represent a substantial fraction of transport intermediates
between organelles. They are extracted from membranes by molecular motors walking along …

Shaping embryonic tissues into their functional morphologies requires cells to control the
physical state of the tissue in space and time. While regional variations in cellular forces or cell …

Stimuli-responsive materials are exploited in biological, materials, and sensing applications.
We introduce a new endogenous stimulus, biomacromolecule crowding, which we achieve …