The microanatomy of the dot-shaped, close-contact sites called podosomes and the
mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B …

Growing evidence suggests that phosphoinositides play an important role in membrane
traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major …

Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for
the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 …

The GTPase dynamin, a key player in endocytic membrane fission, interacts with numerous
proteins that regulate actin dynamics and generate/sense membrane curvature. To …

The GPI‐anchored urokinase plasminogen activator receptor (uPAR) does not internalize
free urokinase (uPA) but readily internalizes and degrades uPA: serpin complexes in a …

Inositol phospholipids represent a minor fraction of membrane phospholipids; yet they play
important regulatory functions in signaling pathways and membrane traffic. The …

This study was designed to identify the set of functions activated in cultured endothelial cells
by the hematopoietic growth factors, granulocyte colony-stimulating factor (G-CSF) and …

Endophilin is a membrane-binding protein with curvature-generating and -sensing properties
that participates in clathrin-dependent endocytosis of synaptic vesicle membranes. …

The c-MET oncogene encodes the receptor for the Hepatocyte Growth Factor/Scatter Factor
(HGF), a cytokine that stimulates the invasive growth of normal and neoplastic cells. The Met/…

Amphiphysin (amphiphysin I), a dominant autoantigen in paraneoplastic Stiff-man syndrome,
is a neuronal protein highly concentrated in nerve terminals, where it has a putative role in …