User profiles for Otto K. Kari
 | Otto KariLaboratory Director, Ph.D. Verified email at helsinki.fi Cited by 1094 |
[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or blindness. …
because many diseases affect the retina and choroid leading to impaired vision or blindness. …
[HTML][HTML] The viral protein corona directs viral pathogenesis and amyloid aggregation
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly
influences their bioactivity. As nanosized obligate intracellular parasites, viruses share …
influences their bioactivity. As nanosized obligate intracellular parasites, viruses share …
[HTML][HTML] Artificially cloaked viral nanovaccine for cancer immunotherapy
Virus-based cancer vaccines are nowadays considered an interesting approach in the field
of cancer immunotherapy, despite the observation that the majority of the immune responses …
of cancer immunotherapy, despite the observation that the majority of the immune responses …
[HTML][HTML] In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow
Methodological constraints have limited our ability to study protein corona formation, slowing
nanomedicine development and their successful translation into the clinic. We determined …
nanomedicine development and their successful translation into the clinic. We determined …
[HTML][HTML] Light-activated liposomes coated with hyaluronic acid as a potential drug delivery system
Light-activated liposomes permit site and time-specific drug delivery to ocular and systemic
targets. We combined a light activation technology based on indocyanine green with a …
targets. We combined a light activation technology based on indocyanine green with a …
Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation
When nanocarriers are administered into the blood circulation, a complex biomolecular layer
known as the “protein corona” associates with their surface. Although the drivers of corona …
known as the “protein corona” associates with their surface. Although the drivers of corona …
Influence of cell membrane wrapping on the Cell− porous silicon nanoparticle interactions
Biohybrid nanosystems represent the cutting‐edge research in biofunctionalization of micro‐
and nano‐systems. Their physicochemical properties bring along advantages in the …
and nano‐systems. Their physicochemical properties bring along advantages in the …
ORP2, a cholesterol transporter, regulates angiogenic signaling in endothelial cells
Oxysterol‐binding protein‐related protein 2 (ORP2), a cholesterol‐PI(4,5)P 2 countercurrent
transporter, was recently identified as a novel regulator of plasma membrane (PM) …
transporter, was recently identified as a novel regulator of plasma membrane (PM) …
Diffusion and protein corona formation of lipid-based nanoparticles in the vitreous humor: profiling and pharmacokinetic considerations
The vitreous humor is the first barrier encountered by intravitreally injected nanoparticles.
Lipid-based nanoparticles in the vitreous are studied by evaluating their diffusion with single-…
Lipid-based nanoparticles in the vitreous are studied by evaluating their diffusion with single-…
Beyond Basic Characterization and Omics: Immunomodulatory Roles of Platelet-Derived Extracellular Vesicles Unveiled by Functional Testing
Renowned for their role in hemostasis and thrombosis, platelets are also increasingly recognized
for their contribution in innate immunity, immunothrombosis and inflammatory diseases…
for their contribution in innate immunity, immunothrombosis and inflammatory diseases…