Supercritical CO 2 has the potential to be an excellent environment within which controlled
release polymers and dry composites may be formed. The low temperature and dry …

The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that
regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a …

Objective. To investigate the efficacy and safety of certolizumab pegol (CZP) in a broad
population of patients with active RA. Methods. In this 12-week, double-blind period of the phase …

Objectives To report 4-year imaging outcomes in the RAPID-axSpA ( NCT01087762 ) study
of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-…

Objectives This 52-week, randomised, double-blind phase IIIb study assessed efficacy and
safety of certolizumab pegol (CZP) as add-on therapy to non-biologic disease-modifying …

The recently characterised 299‐residue human XLF/Cernunnos protein plays a crucial role
in DNA repair by non‐homologous end joining (NHEJ) and interacts with the XRCC4–DNA …

Background The best strategy for maintaining clinical remission in patients with axial
spondyloarthritis (axSpA) has not been defined. C-OPTIMISE compared dose continuation, …

Meiotic recombination generates crossovers between homologous chromosomes that are
essential for genome haploidization. The synaptonemal complex is a ‘zipper’-like protein …

Meiotic chromosomes adopt unique structures in which linear arrays of chromatin loops are
bound together in homologous chromosome pairs by a supramolecular protein assembly, …

In meiosis, homologous chromosome synapsis is mediated by a supramolecular protein
structure, the synaptonemal complex (SC), that assembles between homologous chromosome …