[HTML][HTML] PRMT5 inhibition disrupts splicing and stemness in glioblastoma
…, BC Duong, AM Aman, X Che, X Lan, O Whitley… - Nature …, 2021 - nature.com
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor
growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 (PRMT5) …
growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 (PRMT5) …
Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
Glioblastomas harbor diverse cell populations, including rare glioblastoma stem cells (GSCs)
that drive tumorigenesis. To characterize functional diversity within this population, we …
that drive tumorigenesis. To characterize functional diversity within this population, we …
[HTML][HTML] Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch
Multiple vertebrate embryonic structures such as organ primordia are composed of confluent
cells. Although mechanisms that shape tissue sheets are increasingly understood, those …
cells. Although mechanisms that shape tissue sheets are increasingly understood, those …
[HTML][HTML] Wnt activation as a therapeutic strategy in medulloblastoma
…, L Richards, MM Kameda-Smith, O Whitley… - Nature …, 2020 - nature.com
Medulloblastoma (MB) is defined by four molecular subgroups (Wnt, Shh, Group 3, Group 4)
with Wnt MB having the most favorable prognosis. Since prior reports have illustrated the …
with Wnt MB having the most favorable prognosis. Since prior reports have illustrated the …
[PDF][PDF] Medulloblastoma arises from the persistence of a rare and transient Sox2+ granule neuron precursor
Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously,
we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with …
we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with …
Multi-scale systems genomics analysis predicts pathways, cell types, and drug targets involved in normative variation in peri-adolescent human cognition
An open challenge in human genetics is to better understand the systems-level impact of
genotype variation on developmental cognition. To characterize the genetic underpinnings of …
genotype variation on developmental cognition. To characterize the genetic underpinnings of …
Transcriptional and Multi-Omic Heterogeneity in Glioblastoma Stem Cells
O Whitley - 2022 - search.proquest.com
Glioblastoma Multiforme (GBM) is a disease with terrible prognosis, having a median
survival time of~ 12-15 months for patients undergoing current treatment regimens, and a 5-year …
survival time of~ 12-15 months for patients undergoing current treatment regimens, and a 5-year …
Revelation of shared transcriptional gradients in glioblastoma tumors and cultured glioma stem cells
OK Whitley, LM Richards, F Cavalli, P Guilhamon… - Cancer Research, 2020 - AACR
The brain tumor Glioblastoma (GBM) is a virtual death sentence for anyone who is diagnosed,
with a median survival time of 12-15 months with standard treatments 1 and a 5 year …
with a median survival time of 12-15 months with standard treatments 1 and a 5 year …
CNSC-44. BIOLOGICAL PATTERN DISCOVERY IN GLIOBLASTOMA
…, M Kushida, N Park, F Coutinho, O Whitley… - Neuro …, 2023 - academic.oup.com
Glioblastoma(GBM - IDH wildtype) is an adult glioma, showing abysmal prognosis. Sequencing
technologies show us the existence of a neurodevelopmental frame-work, upon which …
technologies show us the existence of a neurodevelopmental frame-work, upon which …
Oscillatory cortical forces promote three dimensional cell intercalations that shape the mandibular arch
Multiple vertebrate embryonic structures such as organ primordia are composed of a
volume of confluent cells. Although mechanisms that shape tissue sheets are increasingly …
volume of confluent cells. Although mechanisms that shape tissue sheets are increasingly …