Chemoresistance is a major obstacle in triple negative breast cancer (TNBC), the most
aggressive breast cancer subtype. Here we identify hypoxia-induced ECM re-modeler, lysyl …

Purpose: Tamoxifen remains an important hormonal therapy for ER-positive breast cancer;
however, development of resistance is a major obstacle in clinics. Here, we aimed to identify …

Estrogen receptor-positive (ER +) breast cancer accounts for approximately 75% of all breast
cancers. Endocrine therapies, including selective ER modulators (SERMs), aromatase …

Trastuzumab-refractory, HER2 (human epidermal growth factor receptor 2)-positive breast
cancer is commonly treated with trastuzumab emtansine (T-DM1), an antibody–drug …

Cancer cells frequently boost nucleotide metabolism (NM) to support their increased
proliferation, but the consequences of elevated NM on tumor de-differentiation are mostly …

MicroRNAs (miRNAs) are 20–22-nucleotide small endogenous non-coding RNAs which
regulate gene expression at post-transcriptional level. In the last two decades, identification of …

Purpose Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast
cancer that is frequently treated with chemotherapy. However, many patients exhibit either de …

Cancer cells alter their metabolism to support their malignant properties. In this study, we
report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-…

Background Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness,
chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit …

Dysregulation of PI3K and MAPK pathways promotes uncontrolled cell proliferation, apoptotic
inhibition and metastasis. Individual targeting of these pathways using kinase inhibitors …