Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …

When the human genome was sequenced, it came as a surprise that it contains “only”
21,306 protein-coding genes. However, complexity and diversity are multiplied by alternative …

Neurexins are considered central organizers of synapse architecture that are implicated in
neuropsychiatric disorders. Expression of neurexins in hundreds of alternatively spliced …

The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by …

In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the
corresponding mutations produce robust synaptic and behavioral changes. However, different …

Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …

The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present study…

Huntington’s disease (HD), an incurable neurodegenerative disorder, has a complex
pathogenesis including protein aggregation and the dysregulation of neuronal transcription and …

Aggregation and fibril formation of amyloid-β (Aβ) peptides Aβ40 and Aβ42 are central events
in the pathogenesis of Alzheimer disease. Previous studies have established the ratio of …