A better understanding of the drivers of the spread of malaria parasites and drug resistance
across space and time is needed. These drivers can be elucidated using genetic tools. Here, …

The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little
is known about the spatial and genetic structure of the parasite population in that country. …

Background Treatment and control of malaria depends on artemisinin-based combination
therapies (ACTs) and is challenged by drug resistance, but thus far resistance to artemisinins …

Background Adults are frequently infected with malaria and may serve as a reservoir for further
transmission, yet we know relatively little about risk factors for adult infections. In this study…

In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …

Background In Uganda, artemether-lumefantrine is recommended for malaria treatment and
sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug resistance may …

Malaria transmission depends on the presence of Plasmodium gametocytes that are the
only parasite life stage that can infect mosquitoes. Gametocyte production varies between …

Background Targeted next-generation sequencing offers the potential for consistent, deep
coverage of information-rich genomic regions to characterize polyclonal Plasmodium …

High‐throughput Plasmodium genomic data is increasingly useful in assessing prevalence
of clinically important mutations and malaria transmission patterns. Understanding parasite …

Background Tanzania’s Zanzibar archipelago has made significant gains in malaria control
over the last decade and is a target for malaria elimination. Despite consistent …