Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

Historically, the human brain has been conceptually segregated from the periphery and
further dichotomized into gray matter (GM) and white matter (WM) based on the whitish …

… This degree of consistency between the case-control GWAS and the replication data is
highly unlikely to occur by chance (P = 6 × 10 −19 ). The tested alleles surpassed the P < 10 −6 …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …

… mutations had more than expected direct interconnections (P = 0.008), which was consistent
with more overall connectivity to synaptic proteins as a whole (P = 0.005). b, Overlap of …

… Furthermore, enrichment P values were empirically derived by permuting phenotypes within
subgroups of cases and controls, matched on exome-wide identity-by-state, experimental …

… In brain single-cell expression gene set analyses, we found significant associations of
striatal medium spiny neurons (P = 2.02 × 10 −14 ), hippocampal CA1 pyramidal neurons (P = …

… P corrected < 0.5 (or regulatory trait concordance score (RTC) > 0.9) are plotted in colors, with
colors and Sherlock P values noted on top of the graphic (P = 4.07 × 10 −7 and P … eQTL P …

INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …