Small RNAs break out: the molecular cell biology of mobile small RNAs

P Sarkies, EA Miska - Nature Reviews Molecular Cell Biology, 2014 - nature.com
Small RNAs that function in a non-cell autonomous manner are becoming increasingly
recognized as regulatory molecules with the potential to transmit information between cells, …

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

…, A Jawaid, P Sarkies, J Bohacek, P Pelczar… - Nature …, 2014 - nature.com
Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes
and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) …

[HTML][HTML] piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans

…, J Le Pen, G Pintacuda, A Sakaguchi, P Sarkies… - Cell, 2012 - cell.com
Transgenerational effects have wide-ranging implications for human health, biological
adaptation, and evolution; however, their mechanisms and biology remain poorly understood. …

[HTML][HTML] Molecular mechanisms of epigenetic inheritance: possible evolutionary implications

P Sarkies - Seminars in Cell & Developmental Biology, 2020 - Elsevier
Recently interest in multi-generational epigenetic phenomena have been fuelled by highly
reproducible intergenerational and transgenerational inheritance paradigms in several model …

Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements

…, DH Collins, PD Zamore, EA Miska, P Sarkies… - Nature ecology & …, 2018 - nature.com
In animals, small RNA molecules termed PIWI-interacting RNAs (piRNAs) silence transposable
elements (TEs), protecting the germline from genomic instability and mutation. piRNAs …

[PDF][PDF] Epigenetic instability due to defective replication of structured DNA

P Sarkies, C Reams, LJ Simpson, JE Sale - Molecular cell, 2010 - cell.com
p values were calculated using the unpaired t test (two-tailed). (E) Replication efficiency
of the leading-strand template G4 in rev1 mutants. Complementation is with full-length, …

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

P Sarkies, P Murat, LG Phillips, KJ Patel… - Nucleic acids …, 2012 - academic.oup.com
We have previously reported that DT40 cells deficient in the Y-family polymerase REV1 are
defective in replicating G-quadruplex DNA. In vivo this leads to uncoupling of DNA synthesis …

Encyclopaedia of eukaryotic DNA methylation: from patterns to mechanisms and functions

P Sarkies - Biochemical Society Transactions, 2022 - portlandpress.com
… TE methylation is found in basal plants but the pattern of gene body methylation observed
in Arabidopsis is not obvious, with the exception of the pine P. tanae and Charophytes such as …

A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

A Ashe, T Bélicard, J Le Pen, P Sarkies, L Frézal… - elife, 2013 - elifesciences.org
… Furthermore, overlapping RNAs mapping to complementary strands of the viral genome
showed the 2 nt 3ʹ overhang characteristic of Dicer products (p<10−9, χ2 test against a uniform …

[HTML][HTML] Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages

P Sarkies, ME Selkirk, JT Jones, V Blok, T Boothby… - PLoS …, 2015 - journals.plos.org
… Interestingly, although we clearly identified miRNAs in P. varius, including many that are
widely … to identify a Piwi orthologue analysing draft transcriptome data from P. varius (S1 Text). …