Because they mainly do not involve chemical changes, membrane transporters have been
a Cinderella subject in the biotechnology of small molecule production, but this is a serious …

The MODOMICS database has been, since 2006, a manually curated and centralized
resource, storing and distributing comprehensive information about modified ribonucleosides. …

RNA modifications have recently emerged as a widespread and complex facet of gene
expression regulation. Counting more than 170 distinct chemical modifications with far-reaching …

Background To date, several genome-scale network reconstructions have been used to
describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and …

Background Control of growth rate is mediated by tight regulation mechanisms in all free-living
organisms since long-term survival depends on adaptation to diverse environmental …

We present an experimental and computational pipeline for the generation of kinetic models
of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. …

Auxotrophic markers—mutations in genes encoding enzymes in pathways for the biosynthesis
of metabolic building blocks, such as amino acids or nucleotides—are used as selection …

The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in
cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P 3 . PI(3,4,5)P 3 can be …

The availability of label-free data derived from yeast cells (based on the summed intensity of
the three strongest, isoform-specific peptides) permitted a preliminary assessment of protein …

Background To elucidate the biological processes affected by changes in growth rate and
nutrient availability, we have performed a comprehensive analysis of the transcriptome, …