The PCH2 gene of Saccharomyces cerevisiae is required for the meiotic checkpoint that
prevents chromosome segregation when recombination and chromosome synapsis are …

… Moreover, mutation ofDOT1 increases the DNA damage sensitivity of therad24 checkpoint
mutant (San-Segundo and Roeder, unpublished observations), suggesting that Dot1 also …

Mammalian TopBP1 is a BRCT domain–containing protein whose function in mitotic cells is
linked to replication and DNA damage checkpoint. Here, we study its possible role during …

The execution of recombinational pathways during the repair of certain DNA lesions or in
the meiotic program is associated to the formation of joint molecules that physically hold …

During meiosis, accurate chromosome segregation relies on the proper interaction between
homologous chromosomes, including synapsis and recombination. The meiotic …

… Pedro A San-Segundo Pedro A San-Segundo … During meiosis, Dot1 is required for the
meiotic recombination checkpoint (San-Segundo and Roeder 2000) and, in mitotic cells, Dot1-…

Regulation of PCNA ubiquitylation plays a key role in the tolerance to DNA damage in
eukaryotes. Although the evolutionary conserved mechanism of PCNA ubiquitylation is well …

Faithful meiotic chromosome inheritance and fertility rely on the stimulation of meiotic
crossover recombination by potentially genotoxic DNA double-strand breaks (DSBs). To avoid …

Meiotic cells possess surveillance mechanisms that monitor critical events such as
recombination and chromosome synapsis. Meiotic defects resulting from the absence of the …

… Pedro A San-Segundo Pedro A San-Segundo … San-Segundo, unpublished results).
The increased number of Rad52 foci observed in dot1 (Figure 6) and its sensitivity to IR (Game …