Aphids engage in symbiotic associations with a diverse assemblage of heritable bacteria. In
addition to their obligate nutrient-provisioning symbiont, Buchnera aphidicola, aphids may …

… We thank members of the Degnan, Taga, and Goodman labs for helpful discussion. We
appreciate support from NIH grants DK089121 and GM103574 (to ALG) and NSF grant …

Specific members of the intestinal microbiota dramatically affect inflammatory bowel disease
(IBD) in mice. In humans, however, identifying bacteria that preferentially affect disease …

Bacteriophages are known to carry key virulence factors for pathogenic bacteria, but their
roles in symbiotic bacteria are less well understood. The heritable symbiont Hamiltonella …

Resilience to host inflammation and other perturbations is a fundamental property of gut
microbial communities, yet the underlying mechanisms are not well understood. We have found …

Microbes commonly exist in milieus of varying complexity and diversity. Although cultivation-based
techniques have been unable to accurately capture the true diversity within microbial …

Aphids maintain mutualistic symbioses involving consortia of coinherited organisms. All
possess a primary endosymbiont, Buchnera, which compensates for dietary deficiencies; many …

Eukaryotes engage in a multitude of beneficial and deleterious interactions with bacteria.
Hamiltonella defensa, an endosymbiont of aphids and other sap-feeding insects, protects its …

Genomic and metagenomic sequencing efforts, including human microbiome projects,
reveal that microbes often encode multiple systems that appear to accomplish the same task. …

… Hamiltonella defensa” strain 5AT genome (Degnan and Moran, unpublished). The … only
two that showed significant length variation (PH Degnan, unpublished). To determine the cause …