User profiles for P. H. O’Farrell

Patrick H O'Farrell

Professor, Department of Biochemistry, UCSF
Verified email at cgl.ucsf.edu
Cited by 50648

Comparative genomics of the eukaryotes

…, JT Littleton, DK Morrison, C Mungall, PH O'Farrell… - Science, 2000 - science.org
A comparative analysis of the genomes ofDrosophila melanogaster, Caenorhabditis
elegans, and Saccharomyces cerevisiae—and the proteins they are predicted to encode—was …

High resolution two-dimensional electrophoresis of basic as well as acidic proteins

PZ O'Farrell, HM Goodman, PH O'Farrell - Cell, 1977 - cell.com
pH 5-7 and pH 3-10 mixture was not successful since in the presence of urea, the basic
region of the pH … of the pH gradient, the few moderately basic proteins which entered the gel …

[HTML][HTML] High resolution two-dimensional electrophoresis of proteins.

PH O'Farrell - Journal of biological chemistry, 1975 - Elsevier
… gradient because the high concentration of urea causes large changes in pH as well as the
… the pH gradient does not extend significantly above pH 7. Extension of this pH gradient to pH

[PDF][PDF] Embryonic cleavage cycles: how is a mouse like a fly?

PH O'farrell, J Stumpff, TT Su - Current Biology, 2004 - cell.com
The evolutionary advent of uterine support of embryonic growth in mammals is relatively
recent. Nonetheless, striking differences in the earliest steps of embryogenesis make it difficult …

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

…, J Heemskerk-Jongens, JA Kassis, PH O'Farrell - Nature, 1988 - nature.com
… , the major transcription unit with start site (O) and presumed translation start site (AUG) and
the … cannot be due to leakiness of the ptc allele because the same delay is o):,served in ptc1 …

Genetic control of cell division patterns in the Drosophila embryo

BA Edgar, PH O'Farrell - Cell, 1989 - cell.com
… We injected these embryos with 50 mM BrdU (pH 9) during G2 of cycle 14, allowed … and
OFarrell(i989). DNA preparations for Southern blots were carried out as in Lehner and OFarrell (…

The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing

…, A Hekele, A Gillis, E Foley, PH O'Farrell… - Nature cell …, 2006 - nature.com
… and lysed in hypotonic buffer (10 mM HEPES at pH 7.3, 6 mM β-mercaptoethanol, complete
… We are grateful to members of the Andino and O'Farrell labs for support and discussions; G. …

The sequence specificity of homeodomain-DNA interaction

C Desplan, J Theis, PH O'Farrell - Cell, 1988 - cell.com
… We are grateful to the people in the OFarrell lab for their support. In particular, we thank
Steve DiNardo, Jim Jaynes, Jill Jongens, Bill Kalionis, Delia Lakich, Christian Lehner, and John …

The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string

BA Edgar, PH O'Farrell - Cell, 1990 - cell.com
The string (sfg) locus of Drosophila encodes a factor that is thought to trigger mitosis by
activating the p34CdC2 protein kinase. stg is required for mitosis early in development and is …

Progression of the cell cycle through mitosis leads to abortion of nascent transcripts

AW Shermoen, PH O'Farrell - Cell, 1991 - cell.com
… Furthermore, the completed Ubx transcript has a very short lifetime (AW Shermoen and
PH O'Farrell, unpublished data), so that the majority of the life span of a Ubx transcript is …