A human phenome-interactome network of protein complexes implicated in genetic disorders
K Lage, EO Karlberg, ZM Størling, PI Olason… - Nature …, 2007 - nature.com
We performed a systematic, large-scale analysis of human protein complexes comprising
gene products implicated in many different categories of human disease to create a phenome-…
gene products implicated in many different categories of human disease to create a phenome-…
[HTML][HTML] De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
…, À Bayés, E Fernandez, PI Olason… - Molecular …, 2012 - nature.com
A small number of rare, recurrent genomic copy number variants (CNVs) are known to
substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity in …
substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity in …
[HTML][HTML] The genomic landscape of species divergence in Ficedula flycatchers
Unravelling the genomic landscape of divergence between lineages is key to understanding
speciation 1 . The naturally hybridizing collared flycatcher and pied flycatcher are important …
speciation 1 . The naturally hybridizing collared flycatcher and pied flycatcher are important …
[HTML][HTML] The sequences of 150,119 genomes in the UK Biobank
Detailed knowledge of how diversity in the sequence of the human genome affects phenotypic
diversity depends on a comprehensive and reliable characterization of both sequences …
diversity depends on a comprehensive and reliable characterization of both sequences …
Parental origin of sequence variants associated with complex diseases
…, A Jonasdottir, ML Frigge, A Gylfason, PI Olason… - Nature, 2009 - nature.com
Abstract Effects of susceptibility variants may depend on from which parent they are inherited.
Although many associations between sequence variants and human traits have been …
Although many associations between sequence variants and human traits have been …
Disruption of the neurexin 1 gene is associated with schizophrenia
…, H Petursson, A Gylfason, PI Olason… - Human molecular …, 2009 - academic.oup.com
Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have
also been reported in two families with schizophrenia. We examined NRXN1, and the …
also been reported in two families with schizophrenia. We examined NRXN1, and the …
Detection of sharing by descent, long-range phasing and haplotype imputation
…, P Zusmanovich, G Thorleifsson, PI Olason… - Nature …, 2008 - nature.com
Uncertainty about the phase of strings of SNPs creates complications in genetic analysis,
although methods have been developed for phasing population-based samples. However, …
although methods have been developed for phasing population-based samples. However, …
Linked selection and recombination rate variation drive the evolution of the genomic landscape of differentiation across the speciation continuum of Ficedula …
Speciation is a continuous process during which genetic changes gradually accumulate in
the genomes of diverging species. Recent studies have documented highly heterogeneous …
the genomes of diverging species. Recent studies have documented highly heterogeneous …
Copy number variations of chromosome 16p13. 1 region associated with schizophrenia
…, P Muglia, A Gylfason, O Gustafsson, PI Olason… - Molecular …, 2011 - nature.com
Deletions and reciprocal duplications of the chromosome 16p13. 1 region have recently been
reported in several cases of autism and mental retardation (MR). As genomic copy number …
reported in several cases of autism and mental retardation (MR). As genomic copy number …
[HTML][HTML] Large-scale plasma proteomics comparisons through genetics and disease associations
…, TA Olafsdottir, BV Halldorsson, PI Olason… - Nature, 2023 - nature.com
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …