Past studies offer contradictory claims for the role of genome organization in the regulation
of gene activity. Here, we show through high-resolution chromosome conformation analysis …

The prevailing view of metazoan gene regulation is that individual genes are independently
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …

10.7554/eLife.29005.001 Multicellular development is driven by regulatory programs that
orchestrate the transcription of protein-coding and noncoding genes. To decipher this genomic …

Enhancers switch genes on and off in response to a variety of intrinsic and external cellular
signals. They are the cornerstone of gene regulation and the most pervasive constituents of …

Many of the α-proteobacteria establish long-term, often chronic, interactions with higher
eukaryotes. These interactions range from pericellular colonization through facultative …

Eukaryotic cells make many types of primary and processed RNAs that are found either in
specific subcellular compartments or throughout the cells. A complete catalogue of these …

The primary problem with the explosion of biomedical datasets is not the data, not computational
resources, and not the required storage space, but the general lack of trained and …

Many eukaryotic genes possess multiple alternative promoters with distinct expression
specificities. Therefore, comprehensively annotating promoters and deciphering their individual …

Microglial function declines during aging. The interaction of microglia with the gut microbiota
has been well characterized during development and adulthood but not in aging. Here, we …

Symbiosis with arbuscular mycorrhizal fungi (AMF) improves plant nutrition in most land plants,
and its contribution to the colonization of land by plants has been hypothesized. Here, we …