10.7554/eLife.38839.001 PCSK9 is a secreted protein that regulates plasma cholesterol
levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo …

Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular
disease. A critical pathway regulating cholesterol homeostasis involves the receptor-…

Newly synthesized proteins co-translationally inserted into the endoplasmic reticulum (ER)
lumen may be recruited into anterograde transport vesicles by their association with specific …

To achieve a systems-based approach to targeting the antioxidant pathway, 1,4-naphthoquinone
annulated N-heterocyclic carbene (NHC) [bis(1,3-dimesityl-4,5-naphthoquino-imidazol-…

The low-density lipoprotein receptor (LDLR) mediates the hepatic uptake of circulating low-density
lipoproteins (LDLs), a process that modulates the development of atherosclerotic …

Disease progression during SARS-CoV-2 infection is tightly linked to the fate of lung
epithelial cells, with severe cases of COVID-19 characterized by direct injury of the alveolar …

Plasma LDL is produced from catabolism of VLDL and cleared from circulation mainly via
the hepatic LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (PCSK9) …

In the conventional secretory pathway, cargo receptors play important roles in exporting
newly synthesized secretory proteins from the endoplasmic reticulum (ER). We previously …

The worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly.
Although this condition is generally benign, accumulating evidence now suggests that …

CRISPR technologies have progressed by leaps and bounds over the past decade, not only
having a transformative effect on biomedical research but also yielding new therapies that …