Yin Yang 1 (YY1) is a multifunctional protein with regulatory potential in tumorigenesis. Ample
studies demonstrated the activities of YY1 in regulating gene expression and mediating …

… Drafting of the manuscript: Tezal and Smaldino. Critical revision of the manuscript for
important intellectual content: Sullivan Nasca, Stoler, Melendy, Hyland, Rigual, and Loree. …

The promoter in HIV type 1 (HIV-1) proviral DNA contains three sequential guanosines at
the U3–R boundary that have been proposed to function as sites for transcription initiation. …

It has been previously shown that the DHX36 gene product, G4R1/RHAU, tightly binds
tetramolecular G4-DNA with high affinity and resolves these structures into single strands. Here, …

GGGGCC (G 4 C 2 ) hexanucleotide repeat expansions in the endosomal trafficking gene
C9orf72 are the most common genetic cause of ALS and frontotemporal dementia. Repeat-…

Mod5 is the yeast tRNA isopentenyl transferase, an enzyme that is conserved from bacteria
to humans. Mod5 is primarily cytoplasmic where it modifies the A37 position of a few tRNAs, …

The relationship between lipid homeostasis and protein homeostasis (proteostasis) is
complex and remains incompletely understood. We conducted a screen for genes required for …

Ends of human chromosomes consist of the six nucleotide repeat d[pTTAGGG] n known as
telomeric DNA, which protects chromosomes. We have previously shown that the DHX36 …

G-quadruplexes (G4s) are secondary DNA and RNA structures stabilized by positive cations
in a central channel formed by stacked tetrads of Hoogsteen base-paired guanines. G4s …

TRIT1 is a highly conserved tRNA isopentenyl transferase that modifies a subset of tRNAs
in human cells and is a candidate tumor suppressor in lung cancer in certain ethnic …