Drug target identification is a crucial step in development, yet is also among the most
complex. To address this, we develop BANDIT, a Bayesian machine-learning approach that …

The sarcin–ricin loop (SRL) is one of the longest conserved sequences in the 23S ribosomal
RNA. The SRL has been accepted as crucial for the activity of the ribosome because it is …

During protein synthesis, mRNA and tRNAs are iteratively translocated by the ribosome.
Precisely what molecular event is rate limiting for translocation is not known. Here we show that …

Photoexcitation of a solution of anthracene-9-methanol derived esters at ∼386nm in CH 3
CN/H 2 O (3:2 v/v) results in fluorescence emission in the 380–480nm range, with quantum …

Accurate tRNA selection by the ribosome is essential for the synthesis of functional proteins.
Previous structural studies indicated that the ribosome distinguishes between cognate and …

Photocleavable protecting groups are important in synthesis and caging. Among many such
groups, 2-nitrobenzyl and related groups have been found useful in many applications. …

The selection of aminoacyl-tRNAs by the ribosome is a fundamental step in the elongation
cycle of protein synthesis. tRNA selection is a multistep process that ensures only correct …

Drug target identification is one of the most important aspects of pre-clinical development yet
it is also among the most complex, labor-intensive, and costly. This represents a major issue…

Synthesis, photochemistry, and biomolecular caging properties of a new chromophore namely
3-nitro-2-naphthalenemethanol are described. This chromophore is photoexcitable with …

Synthesis, photochemistry and photorelease properties of 7-methoxy-3-nitro-2-
naphthalenemethanol (MNNM) are described. Photoirradiation (⩾ 370 nm) of MNNM …