Schizophrenia is strongly familial yet rarely (if ever) exhibits classical Mendelian inheritance
patterns. The advent of large-scale genotyping and sequencing projects has yielded large …

INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …

Genome-wide association studies (GWAS) have revolutionized our ability to understand the
genetic underpinnings of biomedical traits; however, their extreme Eurocentric bias has …

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …

Background Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease,
are calculated as a weighted count of risk alleles identified in genome-wide association …

Genome-wide association studies (GWAS) for schizophrenia have identified over 100 loci
encoding> 500 genes. It is unclear whether any of these genes, other than dopamine receptor …

Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While the coding
change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only …

Genetic correlation is a key population parameter that describes the shared genetic architecture
of complex traits and diseases. It can be estimated by current state-of-art methods, ie, …

… Second, we used the “easy-HiC” readouts obtained from adult temporal cortex as described
in Giusti-Rodríguez et al. . “Easy Hi–C” was applied to six postmortem samples (N = 3 adult …

Most human genetic studies assume that connections between genomic regions are adequately
captured by linkage disequilibrium (LD). LD reflects historical events that shaped the …