Tau proteins belong to the family of microtubule-associated proteins. They are mainly expressed
in neurons where they play an important role in the assembly of tubulin monomers into …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Neurodegenerative disorders are characterized by extensive neuron death that leads to
functional decline, but the neurobiological correlates of functional decline in normal aging are …

Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources
to complement genomic sequence data and to correlate functional and genetic brain …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

… Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science . … Bussière,
Bouras, Perl, Morrison, and Hof) and Departments of Geriatrics and Adult Development (Drs. …

We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

Stressful life events have been implicated clinically in the pathogenesis of mental illness,
but the neural substrates that may account for this observation remain poorly understood. …

Both the hippocampus and the medial prefrontal cortex (mPFC) play an important role in the
negative feedback regulation of hypothalamic–pituitary–adrenal (HPA) activity during …

Numerous lines of inquiry implicate connectivity as a central abnormality in schizophrenia.
Myelination and factors that affect myelination, such as the function of oligodendroglia, are …