Facilitated by recent advances using CRISPR/Cas9, genome editing technologies now
permit custom genetic modifications in a wide variety of organisms. Ideally, modified animals …

Much attention has focused on the aetiology of oxidative damagein cellular and organismal
ageing 1 , 2 , 3 , 4 . Especially toxic arethe reactive oxygen byproducts of respiration and …

Intracellular oxidative stress from mitochondria is thought to be important in carcinogenesis
and tumorigenesis, but direct experimental proof is limited. In this study, a transgenic mouse …

A mev-1(kn1) mutant of the nematode Caenorhabditis elegans is defective in the cytochrome
b large subunit (Cyt-1/ceSDHC) in complex II of the mitochondrial electron transport chain. …

The mev-1 gene encodes cytochrome b, a large subunit of the Complex II enzyme succinate-CoQ
oxidoreductase. The mev-1(kn1) mutants are hypersensitive to oxidative stress and …

Mitochondria play a role of energy production and produce intracellular reactive oxygen
species (ROS), especially superoxide anion (O 2 − ) as a byproduct of energy metabolism at the …

… HERMAN, CK KARI and PS HARTMAN, unpublished results). None of the him mutants
showed significant departures from the wild-type pattern of radiation resistance (see below). The …

… for rad-3 (Hartman and Mitchell, personal communication). It has … Hartman, PS UV irradiation
of wild-type and radiation-sensitive … Hartman, PS Effects of age and liquid holding on the UV …

… A second, unlinked mutation was responsible for this male-specific lethality (Hartman,
unpublished). The few resulting mev-1/+ males were mated to the unc-79 dpy-17; unc-7 gas-1 …

The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging,
including the roles of oxidative stress and protein damage. In this review, we focus on the …