Lewy bodies, the characteristic pathological lesion of substantia nigra neurons in Parkinson’s
disease (PD), are frequently observed to accompany the amyloid plaque and …

Alpha-synuclein (α-syn) and tau polymerize into amyloid fibrils and form intraneuronal
filamentous inclusions characteristic of neurodegenerative diseases. We demonstrate that α-syn …

THE normal development of the vertebrate nervous system entails the death of 30–70% of the
neurons originally generated in most neuronal populations 1 . This naturally occurring cell …

Recent experimental evidence suggests that transcellular propagation of fibrillar protein
aggregates drives the progression of neurodegenerative diseases in a prion-like manner. This …

Objective The objective of this study was to evaluate the relationship between Parkinson's
disease (PD) with dementia and cortical proteinopathies in a large population of …

A novel neurotrophic factor named Persephin that is ∼40% identical to glial cell line–derived
neurotrophic factor (GDNF) and neurturin (NTN) has been identified using degenerate PCR…

α-Synuclein (SYN) is the major component of Lewy bodies, the neuropathological hallmarks
of Parkinson's disease (PD). Missense mutations and multiplications of the SYN gene cause …

Objective: Mutations in the gene encoding phospholipase A 2 group VI (PLA2G6) are
associated with two childhood neurologic disorders: infantile neuroaxonal dystrophy (INAD) and …

The transcription of heat shock genes in response to physiological stress requires activation
of heat shock transcription factor (HSF). Although the transcriptional response is most …

Purpose This review provides an account of the current status of the development of PET
radiotracers for imaging aggregated alpha synuclein (α-syn) in Lewy bodies and Lewy neurites…