Mitochondria exist in dynamic networks that undergo fusion and fission. Mitochondrial fusion
and fission are mediated by several GTPases in the outer mitochondrial membrane, notably …

Rationale: Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by
pulmonary vascular obstruction caused, in part, by pulmonary artery smooth muscle cell (…

Background— Excessive proliferation and impaired apoptosis of pulmonary artery (PA)
smooth muscle cells (PASMCs) contribute to vascular obstruction in patients and fawn-hooded …

Right ventricular hypertrophy (RVH) and RV failure contribute to morbidity and mortality in
pulmonary arterial hypertension (PAH). The cause of RV dysfunction and the feasibility of …

Background The results from cross sectional and longitudinal studies show that periodontitis
is closely associated with cognitive impairment (CI) and Alzhemer’s Disease (AD). Further, …

It has previously been observed that expression of chemokine monocyte chemoattractant
protein‐1 (MCP‐1/CC chemokine ligand 2 (CCL2)) and its receptor CC chemokine receptor 2 (…

Human mesenchymal stem cells (MSCs) are adult multipotent stem cells which can be
isolated from bone marrow, adipose tissue as well as other tissues and have the capacity to …

Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …

Hypercapnia (elevated CO 2 levels) occurs as a consequence of poor alveolar ventilation
and impairs alveolar fluid reabsorption (AFR) by promoting Na,K-ATPase endocytosis. We …

Right ventricular hypertrophy (RVH) and RV failure are major determinants of prognosis in
pulmonary hypertension and congenital heart disease. In RVH, there is a metabolic shift from …