Stem cell fate is influenced by a number of factors and interactions that require robust
control for safe and effective regeneration of functional tissue. Coordinated interactions with …

… Zandstra PWGeneration of human embryonic stem cell-derived mesoderm and cardiac
cells … , M., Kumacheva, E., and Zandstra, PW Generation of human embryonic stem cell-derived …

Stem cells have emerged as the starting material of choice for bioprocesses to produce
cells and tissues to treat degenerative, genetic, and immunological disease. Translating the …

Transforming growth fazctor-β (TGFβ) family members regulate many developmental and
pathological events through Smad transcriptional modulators. How nuclear accumulation of …

Refractoriness to induction chemotherapy and relapse after achievement of remission are
the main obstacles to cure in acute myeloid leukaemia (AML) 1 . After standard induction …

The small number of hematopoietic stem and progenitor cells in cord blood units limits their
widespread use in human transplant protocols. We identified a family of chemically related …

To better understand endogenous parameters that influence pluripotent cell differentiation
we used human embryonic stem cells (hESCs) as a model system. We demonstrate that …

Background Human embryonic stem cells (hESC) should enable novel insights into early
human development and provide a renewable source of cells for regenerative medicine. …

Embryonic stem (ES) cells have tremendous potential as a cell source for cell‐based therapies.
Realization of that potential will depend on our ability to understand and manipulate the …

Complexity in the spatial organization of human embryonic stem cell (hESC) cultures
creates heterogeneous microenvironments (niches) that influence hESC fate. This study …