User profiles for P. Alcami

Pepe Alcami

Ludwig-Maximilians-University, Munich and Max Planck Institute for Ornithology, Seewiesen
Verified email at bio.lmu.de
Cited by 463

Beyond plasticity: the dynamic impact of electrical synapses on neural circuits

P Alcamí, AE Pereda - Nature Reviews Neuroscience, 2019 - nature.com
… Transmission at most chemical synapses is intermittent, as transmitter release is probabilistic
(P < 1) and depends on the presence of an action potential in the presynaptic terminal (…

[HTML][HTML] Axonal computations

P Alcami, A El Hady - Frontiers in Cellular Neuroscience, 2019 - frontiersin.org
Axons functionally link the somato-dendritic compartment to synaptic terminals. Structurally
and functionally diverse, they accomplish a central role in determining the delays and …

Somatostatin-positive interneurons in the dentate gyrus of mice provide local-and long-range septal synaptic inhibition

…, L Ansel-Bollepalli, A Foggetti, P Wulff, P Alcami… - Elife, 2017 - elifesciences.org
… in GCs (p=0.0037 and p=0.00074, respectively, Wilcoxon Rank Sum test; Figure 4D). This
is further reflected in a ~sixfold higher amplitude ratio between IPSCpsoma and IPSComl in …

Measuring the firing rate of high-resistance neurons with cell-attached recording

P Alcami, R Franconville, I Llano… - Journal of …, 2012 - Soc Neuroscience
… the firing rate by twofold, so that R p is close to the ratio R = 22/… We turn below to a more
rigorous evaluation of R p that takes … The resistive part of Z p , called R p , is a combination of two …

Adaptive introgression of a visual preference gene

M Rossi, AE Hausmann, P Alcami, M Moest… - Science, 2024 - science.org
Visual preferences are important drivers of mate choice and sexual selection, but little is known
of how they evolve at the genetic level. In this study, we took advantage of the diversity of …

Estimating functional connectivity in an electrically coupled interneuron network

P Alcami, A Marty - Proceedings of the National Academy of …, 2013 - National Acad Sciences
P values for the comparison of the somatodendritic and axonal time constants τ 1 and τ 2
were, respectively, 0.26 and 0.51 (Wilcoxon–Mann–Withney two-sample rank test), confirming …

[HTML][HTML] The carboxyl-terminal domain of connexin43 is a negative modulator of neuronal differentiation

MF Santiago, P Alcami, KM Striedinger… - Journal of Biological …, 2010 - ASBMB
… After decapitation, the embryonic brains were fixed in 4% p-formaldehyde overnight and
then transferred to a cryoprotective solution (30% sucrose in phosphate-buffered saline). …

[HTML][HTML] Electrical synapses enhance and accelerate interneuron recruitment in response to coincident and sequential excitation

P Alcami - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Electrical synapses are ubiquitous in interneuron networks. They form intercellular pathways,
allowing electrical currents to leak between coupled interneurons. I explored the impact of …

[HTML][HTML] Extensive GJD2 Expression in the Song Motor Pathway Reveals the Extent of Electrical Synapses in the Songbird Brain

P Alcami, S Totagera, N Sohnius-Wilhelmi, S Leitner… - Biology, 2021 - mdpi.com
Simple Summary Electrical synapses are ubiquitous in nervous systems, where they coordinate
the activity of neural networks in time. However, their role in the execution and learning …

Mitochondria induce anisotropy and delays in action potential conduction

A Castelfranco, P Alcami - bioRxiv, 2023 - biorxiv.org
… The p and r values from a linear correlation test are indicated. … axons with 10% longitudinal
coverage at the RA (p = 0 in purple, p = 0.4 in dark blue and p = 0.8 in turquoise). D1. Action …