Post-translational modification of proteins by ubiquitin is a fundamentally important regulatory
mechanism. However, proteome-wide analysis of endogenous ubiquitylation remains a …

Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN),
NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to …

The regulatory networks of the DNA damage response (DDR) encompass many proteins
and posttranslational modifications. Here, we use mass spectrometry-based proteomics to …

… P ≥ 0.05). Individual data points are plotted over bars, and statistical source data including
the precise P … Statistical source data including precise P values are shown in Supplementary …

… Asterisk indicates statistical significance p < 2.2eÀ16 by Wilcoxen test. See also Figures
S3E… Asterisk indicates statistical significance p < 2.2eÀ16 by Wilcoxen test. (E) Graph showing …

… Heatmap represents P-values for each term in comparison to whole mouse proteome.
The numbers within boxes indicate hyperacetylated proteins covering the percent of proteins …

Posttranslational modifications of proteins increase the complexity of the cellular proteome
and enable rapid regulation of protein functions in response to environmental changes. …

N 6 -methyladenosine (m 6 A) is the most abundant internal modification on mRNA which
influences most steps of mRNA metabolism and is involved in several biological functions. The …

Protein ubiquitylation has emerged as a key regulatory mechanism in DNA-damage signalling
and repair pathways. We report a proteome-wide, site-specific survey of ubiquitylation …

Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging
chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-…